Dissertation > Excellent graduate degree dissertation topics show

Antiinflammatory Effects of Effective Extracts of Longteng Capsule and Its Mechanisms in Rats

Author: DuBenJun
Tutor: LiXiaoHui
School: Third Military Medical University
Course: Pharmacology
Keywords: Longteng Capsule rheumatoid arthritis analgesia inflammation immunity cytokine
CLC: R285
Type: Master's thesis
Year: 2005
Downloads: 69
Quote: 0
Read: Download Dissertation

Abstract


Rheumatoid arthritis (RA) is a kind of autoimmunity desease and tends to cause diversity degree disability. In recent years, though some progress had been acquired in the field of RA research, many problems are still to be solved, such as the mechanisms of RA and the discovery of novel antiinflammatory drug with low side effect, etc. Natural plants and traditional Chinese medicine is the dominant field in the research and development of new drug in our country. Longteng Capsule is an traditional recipe and have good therapeutic effects on RA, but its mechanisms is unclear. In order to find better drug for RA treatment and to sdudy the mechanisms of Longteng Capsule, various inflammatory animal models were implied to research its antiinflammatory and immunoregulatory effects.METHODS1. Rats were divided randomly into 7 groups (n=10), namely normal control, inflammatory model, NS control, theraputic groups (4.5, 1.5, 0.5 g/kg) and positive control (indomethacin theraputic).2. In the acute inflammatory edema rats, the perimeter and weight of paws were measured to calculate the swelling rate and compare the inhibition ratio of every group.3. In the chronic granuloma induced by cotton ball expriments, the weight of granuloma was measured to value the therapeutic efficacy of theraputic groups.4. The content of Evans blue effused was detected with chromatometry to compare the capillary permeability in rats.4.In the hot plate experiment and writhing essay, the act of laping metapedes and frequency of writhing was observed to compare the alteration of pain threshold and the analgesic effect.5.In the Freund’s adjuvant arthritis models:①Aarthritis scrore were valued at 14th,15th,18th,20th,23th,26th,28th day;②At the 28th day of the trial, the gastric mucosa and membrane synovialis were observed morphologically by HE staining. The pathomorphological changes of synovialis and the arthritis index (AI) were assayed.③At

Related Dissertations

  1. The Research of a Novel High Efficiency PFC Circuit Based on One Cycle Control,TM46
  2. Construction of the Recombinant of HSV-2gD Minotope、 HBsAg、 IL-18 DNA Vaccines and Its Inducing Immune Respons in Mice,R392
  3. Blockage type of rheumatoid arthritis clinical research for Zhou Naiyu academic thinking and clinical experience and Bi Yu Kang I,Treatment of late alpine,R259
  4. Identification of B.melitensis 16M Protein Immunodominant Antigens,S852.61
  5. Applied Research of Hemicell? Feed Additive in Weaned Piglets,S828.9
  6. Effects of Varying Levels of Potassium Supplementation to the Low Salinity Waters or Diets on Growth and Physiological Characteristics of Shrimp, Litopenaeus Vannamei, Boone,S963
  7. Effects of Several Immunostimulants on the Growth Performance, Non-specific Immunity and Disease Resistance of Cobia, (Rachycentron Canadum),S963
  8. AttM Transgenic Colored Calla Lily and Antibodies Preparation of Ahl-Degrading Enzyme AttM,S682.264
  9. Effect of Extremely Low Protein Diet to Meishan Gilt on Its Farrowing Performance and Characteristics and Immunity of Its Offspring,S828
  10. Molecular Biological Characteristics of Multiple Porcine Fc Gamma RⅡB Sub-isoforms Generated by Alternative Splicing,S828
  11. Infectious Bursal Disease Virus Particle Vaccine Research and Its Immune Efficacy Evaluation,S858.31
  12. Effect of Oral Immunization with Inactivated Avian H9N2 Influenza Virus on the Local Digestive Tract and Systemic Immunity in Ducks,R392
  13. The Effect and Mechanism of p38MAPK Inhibitor CBS3830 on Intimal Hyperplasia in Autogenous Vein Grafts of Diabetic Rats,R587.1
  14. Effect of Probiotics on Growth Performance, Digestive Enzymes Activities, Immunity and Gut Microbiota of Epiniphelus Coioides,S917.4
  15. Investigate Patients with Rectal Flurbiprofen on Postoperative Immune Function,R614
  16. The Experimental Research of RNAi Technology Inhibiting Respiratory Syncytial Virus,R725.6
  17. Study on Cadmium Enrichment in Aquatic Animals and Its Effect of the Growth, Digestive Enzyme Activities,S917.4
  18. The Function of Fuantang Treating POI in Mice Model and the Mechanism Related with Mast Cell,R285.5
  19. Correlative Study on Plasma Level of Resistin in Patients with Coronary Atherosclerosis Disease,R541.4
  20. Effects of Blockade of IL-17 in Already Established Asthma of BALB/c Mice,R562.25
  21. Changes of Immunologic Function in Patients with Chronic Obstructive Pulmonary Disease and the Intervention by BCG Polysaccharides Nucleic Acid,R563.9

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology
© 2012 www.DissertationTopic.Net  Mobile