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Expression and Significance of HIF-1α in Epithelial Ovarian Neoplasms

Author: XiaoYingLi
Tutor: LiangZhiQing
School: Third Military Medical University
Course: Obstetrics and Gynaecology
Keywords: ovarian neoplasms hypoxia-inducible factor-1α cyclooxygenase-2 microvessel density proliferating cell nuclear antigen immunohistochemistry
CLC: R737.31
Type: Master's thesis
Year: 2005
Downloads: 49
Quote: 0
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Abstract


Backbround:Hypoxia is a common feature of most solid cancers,tumours adopt two ways to comform the low oxygen levers : glycolysis and angiogenesis. Hypoxia-inducible factor-1(HIF-1) is a transcription factor which present in most of mammal and human tissue in the hypoxia condition. HIF-1 alpha,is the only subunit which adjust the oxygen metabolism and determinate HIF’s activity. HIF-1’s target gene is related to tumor cells energy metabolism、angiogenesis、metastasis and Ion metabolism .It is very important that the HIF-1’s position and function in oncologic pathology.Based on this we inspected the expression and significance of HIF-1αin epithelial ovarian neoplasms, it would provide some clues leading to effective diagnosis and treatment strategies for ovarian neoplasms.Part I Expression of HIF-1αin Epithelial Ovarian NeoplasmsObjective:To investigate the expression of hypoxia-inducible factor-1α(HIF-1α) in epithelial ovarian neoplasms and to analyze the relationships between the HIF-1αand the clinicopathological characteristics. Materials and Methods:1. The expression of HIF-1αproteins in 32 benign cystadenomas and 11 borderline tumors and 44 epithelial ovarian carcinomas was detected by immunohistochemistry, followed by light microscopic examination.2. The expression of HIF-1αproteins in benign cystadenomas and borderline tumors and epithelial ovarian carcinomas was analyzed, and the correlation was also analyzed between the expression of HIF-1αand the clinicopathological characteristics such as clinical stage, histological type ,lymphatic metastasis and pathologic grade.

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Ovarian tumors
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