Dissertation > Excellent graduate degree dissertation topics show

Inhibitory Effect and Mechanism of Nordy Eye Drop on Rat’s Corneal Neovascularization Induced by Alkali Cauterization

Author: LiuDanNing
Tutor: XieHanPing
School: Third Military Medical University
Course: Ophthalmology
Keywords: Nordy alkali cauterization corneal neovascularization vascular endothelial growth factor receptor
CLC: R779.1
Type: Master's thesis
Year: 2006
Downloads: 86
Quote: 0
Read: Download Dissertation

Abstract


Background and Aims Corneal neovascularization (CRNV) is one of the severe complications of cornea disease. Hitherto, there are still no efficient drugs to prevent its development with few side effects. Nordihydroguaiaretic acid (NDGA), as a specific inhibitor of lipoxygenase (LOX), is responsible for the inhibition of tumorous and nontumorous angiogenesis. Nordy is a chiral compound based on the chemical structure of NDGA, which is synthesized in our laboratory previously and remaining the antiangiogenesis effect of NDGA without its side effect. It has been confirmed that systemic application of Nordy can suppress the development of diabetic retinopathy through by inhibiting retinal neovascularizaton of retinal. This study is designed to observe the effect on corneal neovascularization, corneal opacity and corneal epithelial wound healing after dropping Nordy in the corneas of Long-Evans rats after alkali injury with three concentrations, and to investigate the inhibitory mechanism of Nordy eye drop with the optimal concentration to provide theoretical foundation for clinical application in the future.Methods1. 0.025%, 0.1%, 0.4% Nordy eye drops that were fulfilled with the criterion of pharmaceutics were prepared.2. The toxicity effects and side effects were observed by praxiology, slit-lamp biomicroscope, light microscope and transmission electron microscope, after 21days at first drop to normal Long-Evans rat’s cornea with 0.025%, 0.1%, 0.4% Nordy eye drops.3. Inflammatory corneal neovascularization models induced by alkali cauterization were made in Long-Evans rats which were distributed randomly into 5 groups: negative control group of Nordy solvent, treatment groups of 0.025%, 0.1% or 0.4% Nordy eye drop and positive control group of 0.1% Dexamethasone sodium phosphate eye drop. Every group was given the above eye drops 4 times per day for 14d. The growth of corneal neovascularization, the level of corneal opacity and the corneal epithelial healing were

Related Dissertations

  1. Studies on the Molecular Mechanism of Anti-HBV Effect of Green Tea Extract Epigallocatechin Gallate,R285
  2. The Involvement of Adenosine in Cardioprotective Effect of Intracerebroventricular Morphine Preconditioning on Myocardial Postischemia Injury,R542.22
  3. The Expression of MMP-2、 VEGF and Ki-67 and Human Glioma Grade,R739.41
  4. The Research on Treatment of Lentivirus-mediated hVEGF-165 Gene Transferring Mesenchymal Stem Cells on Rat Hind Limb Ischemia,R329
  5. Effects of Ginsenoside Rg1 on Cell Proliferation, Secretion Function and ERK、p38 Signal Molecular in Human Umbilical Cord Blood Mesenchymal Stem Cells under Optimized Culture Condition,R285.5
  6. BMP2 and VEGF165 Genes Transfected Rat Bone Marrow Mesechymal Stem Cells Simultaneity Expression,R329
  7. Effects of Receptor Activity Modifying Protein-1 Transplantation of Mesenchymal Stem Cells on Postangioplasty Restenosis and Cardiac Function after Myocardial Infarction in Rabbits,R542.22
  8. Change and Value of Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Coronary Syndrome,R541.4
  9. Expression of Protease-activated Receptor-2 in Lung Injury of Rats with Different Ventilatory Volumes,R563.8
  10. Expression of TNF-α, MMP-9 and VEGF in BALF of Rats with Emphysema and Their Mutual Relationship,R563.3
  11. The Influence of Bile Duct Partial Obstruction on Guinea Pigs’ Sphincter of oddi in Early Stage,R657.4
  12. Expression of Chemokine Receptor CCR5 in Human Non-small-cell Lung Cancer,R734.2
  13. Expression and clinical significance of EGFR and downstream signaling molecules in ovarian cancer,R737.31
  14. Meningiomas and MMP-9, VEGF expression and tumor angiogenesis and recurrence,R739.45
  15. Correlation between CT Perfusion Imaging in Nonsmall-cell Lung Cancer and VEGF、MVD、VEGF-C、LVD,R734.2
  16. The Effect of siRNA Targeting MIF on the Growth of Colorectal Neoplasms Xenografts and the Life Quality of Tumor-bearing Mice,R735.34
  17. The Roles and Mechanism of HIF-2α in Pathogenesis of Ischemic/Hypoxic Acute Kidney Injury,R692
  18. Study of Serum Affected the THP-1 Cell TLR4/NF-κB Signal Pathway in Obese People,R589.2
  19. The Effect of Exercise on the Expression of PPAR-α and Lipid Metabolism in Skeletal Muscle of ApoE Knockout Mice,R587.1
  20. Urotensin Ⅱ Receptor Mediates the Expression of Interleukin-6 in Rat Adventitial Fibroblasts Stimulated by Homocysteine,R543.5
  21. Beidan Yifei on Angiogenesis in Rats with Idiopathic Pulmonary Fibrosis Effects of ET-1 and VEGF,R285

CLC: > Medicine, health > Ophthalmology > Eye injury with foreign body
© 2012 www.DissertationTopic.Net  Mobile