Dissertation > Excellent graduate degree dissertation topics show

NMDA Receptor Participates Mediation of Activation of Spinal Astrocytes during Bee Venom-induced Inflammatory Pain and Hyperalgesia

Author: MengWenGe
Tutor: LiWenBin
School: Hebei Medical University
Course: Pathology and Pathophysiology
Keywords: pain N-methyl-D-aspartic acid glia glial fibrilary acidic protein MK-801 Bee venom
CLC: R402
Type: Master's thesis
Year: 2005
Downloads: 65
Quote: 0
Read: Download Dissertation


At the level of the spinal cord, pathological pain is clasically viewed as being developed and maintained solely by neurons. Glia (microglia and astrocyte) was not considered to play a role in pathologocal pain as they could not function in cell-to-cell synaptically signaling. Howerer, recent evidence shows the important role of spianl glia in development and maintenance of pathologocal pain. For example, spinal glia can be activated by such diverse mainpulations as subcutaneous inflammation, neuropathy, and spinal immune activation. Activated glia ralease a variety of neuroactive substances, including reactive oxygen species, nitric oxide, arachidonic acid, prostaglandins, leukotrienes, excitatory amino acid including glutamate, aspartate and cysteine, nerve growth factors, and so on. Furthermore, like immune cells, activated astrocytes and microglia release proinflammatory cytokines such as interlukin -1 and 6, tumor necrosis factor. Pre-treatment with fluorocitrate or CNI-1493, the inhibitor of glial metabolism, produces a singnifcant analgesia in pathological pain. The above evidence suggests that the activation of astrocyte of the spinal cord is necessary in development and maintenance of pathological pain

Related Dissertations

  1. The Treatment Effect and Mechanism of Ketanserin on Inflammatory and Neuropathic Pain,R741
  2. Application Study of Urethral Catheterization Patient by Using Lidocaine Hydrochride after Hemorrhoid Operation with Urinary Retention,R472
  3. The Roles of Spinal Cord Glia in Bee Venom-induced Nociception and Inflammation in Concious Rats,R741
  4. Antibiotic-resistance of Helicobacter Pylori and Effects of Helicobacter Pylori Eradication on Different Subtypes of Functional Dyspepsia,R57
  5. Clinical observation of qi and nourishing yin blood circulation side treatment of restenosis after PCI,R285
  6. A Preliminary Study of the Effects of Repetitive Transcranial Magnetic Stimulation (RTMS) on Neuropathic Pain in Rats,R741
  7. High-intensity Focused Ultrasound in Combination with Chemotherapy for Treatment of Advanced Pancreatic Cancer,R735.9
  8. The Pain of Survival-The Interpretation of Sophie’s Spiritual Crisis in ’Sophie’s Choice’,I207.42
  9. Behavioral Changes and Expression of FosB/△FosB in the Brain of Kunming Mice Induced by MK-801,R749.3
  10. To Observation of Clinical Efficacy Which Acupuncture Point BL65 in the Treatment of the Postoperative Pain of Milligan-Morgan Operation (A Surgical Treatment of Mixed Hemorrhoids),R246.9
  11. The Protective Effect and Machanism of ZYJN on Experimental Liver Injury,R29
  12. Electro-acupuncture’s Study on the Impact of Trauma Pain’s Circadian Rhythm,R245
  13. Hippocampal NMDA receptors are involved in chronic stress by SP-NK1 receptor pathway induced depression-like behavior,R749.4
  14. Chinese medicine outside treat cancer pain Clinical evaluation and Speculation,R273
  15. The Effect of Exercise-induced Fatigue on Pain Threshold and the nNOS Expression in Rat Spinal Cord,G804.5
  16. Effects of Neonatally Persistent Inflammatory Nociception on Pain Sensitivity and Expression of Spinal NGF, TrkA, BDNF, TrkB,IL-IP-1β, and COX2 in Mature Rats,R722.1
  17. The Experimental Study on Antinociceptive Efficacy of Pre-emptive Intrathecal Administration of CRH and Its Expression in Dorsal Horn of Spinal Cord during Formalin-induced Inflammatory Pain,R402
  18. Analgesia Effect of Ondansetron on the Experimental Animal Pain Model,R96
  19. The Curative Effect Analysis of United Application of Half Mannitol and Sodium Aescinate in Soft Tissue Injuries of Crus,R658.3
  20. Imaging Diagnosis and Clinical Significance of the High-Intensity Zone (HIZ),R445.2

CLC: > Medicine, health > Clinical
© 2012 www.DissertationTopic.Net  Mobile