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Effects of Intestinal RNA on Intestinal Immune after Radiation Damage

Author: SuXiaoMing
Tutor: ZengGuiYing；RenDongQing
School: Fourth Military Medical University
Course: Radiation Medicine
Keywords: Ionizing radiation Intestinal RNA Mice Crypt survival rate Bacterial translocation Endotoxin Cell cycle Lymphocyte Ig Immunohistochemistry Apoptosis Chemiluminescence
CLC: R818
Type: Master's thesis
Year: 2006
Downloads: 68
Quote: 0
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Abstract


In course of nuclear war, nuclear radiation accident and radiation therapy of abdominal tumor, ionizing radiation can often evoke hematopoiesis damage and death of intestine epithelium stem cells and enteric radiation injury, even lead to death of animals for enter radiation disease. Therefore, how to reduce intestinal irradiation injury and promote intestinal repair, has been one of criticality of improving treatment level of acute radiation disease. Departed findings indicated that intestinal RNA can improve crypt survival rate of mice after irradiation damage and promote repair of injuried intestinal tract through regulating enteric epithelium cell cycle and some intestinal gene expression. The research also indicated at different time points nucleic acid can promote repair of crypt cells after radiation damage, and cause hypsi-expression of immunoglobulin genes, and this indicates that intestinal immune system participates repair of crypt cells after irradiation. However, the concrete mechanism that nucleic acid promoted repair to intestinal immune after radiation damage are not yet clear. In the study, 60Co was used as irradiation source to study changes of intestinal immune and mechanism in course of repair of intestinal RNA to intestinal tract after radiation damage for providing academic and experimental gist for research of repair and cure of ionizing radiation injury and improving treatment level of acute radiation disease.

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CLC: > Medicine, health > Of Medical > Radiation Medicine > Radiation sickness,radiation damage
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