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The neck paralysis Shu particle disease rat model of power imbalance cervical degenerative disc tissue

Author: WangKun
Tutor: ZhouLinDong
School: Nanjing University of Traditional Chinese Medicine
Course: TCM orthopedics and traumatology
Keywords: Cervical spondylosis Cervical intervertebral discs Degeneration Apoptosis Animal model Dynamic equilibrium Maladjustment JingBiShu powder
CLC: R285
Type: Master's thesis
Year: 2006
Downloads: 81
Quote: 0
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Abstract


Objective: To establish an ideal model of the experimental cervical spondylosis and to elucidate the molecular mechanism of JingBiShu Powder to inhibit the degeneration of intervertebral disc. Methods: Experiment 1: 24 three month old SD rats were randomly divided into two groups (12 for the experimental group and 12 for the control group). The cervical dorsal extensors of each rat in experimental group were excised. 3 months later all the rats were killed. Pathologic histology of the cervical vertebrae was observed in a light microscope after HE staining. Experiment 2: 48 three months old SD rats were randomly divided into four groups. A, B, C, group were experimental model of cervical intervertebral disc degeneration, D group was the normal control group (sham-surgery). The rats of A and B group were treated with JingBiShu Powder and JingFuKang respectively. Using HE staining and terminal deoxynucleotidyl transferase- mediated dUTP nick end labeling (TUNEL) technique, we assessed the morphologic state of the discs and observed the density of apoptosis cells of the intervertebral disc in every group, then com pared with each other separately. Results: Experiment 1: The results revealed that cervical vertebrae of rat in the experimental group degenerated faster and more seriously than that in the control group. The pathological changes were similar to those of the cervical spondylosis in the human being. Experiment 2: The degree of intervertebral disc degeneration was significant higher in the discs of C group compared with that in A and B group respectively (P<0.05, P<0.01). The apoptosis index of the discs was significant lower in D group compared with A group, B group and C group separately (P<0.05), and the index was higher in C group than that in A or B group, but there were not significant difference (P<0.05). Conclusion: Cervical muscles as well as others of tissue (cervical dynamic equilibrium) have a great significance in course of pathogenesis of

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