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Preparation, Characterisation and Primary Application of a Panel of MAbs Against Haemagglutinin of High Pathogenic H5 Avian Influenza Virus

Author: ChenYiZuo
Tutor: XiaNingShao
School: Xiamen University
Course: Cell Biology
Keywords: H5N1 HA McAb
CLC: S854.4
Type: Master's thesis
Year: 2005
Downloads: 117
Quote: 0
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Abstract


Six persons were killed in the first outbreak of high pathogenic H5N1 avain influenza virus in Hong Kong in 1997. H5N1 began to attack southeastern and central Asia since late 2003. In addition to causing fatal human diseases with 63 people dead, this new outbreak of H5N1 virus severely smashered the agricultural economy and led heavy loss of national economy in the outbreaking country. WHO has already warned the whole world, pointed out that the H5N1 virus would become the candidate for the next pandemic influenza and has already launched to organize the government all over the world to participate the pandemic prepareness plan. But the biggest weakness of this plan is the lack of rapid diagnostic tests for influenza. Obviously, it is urgent to develop a rapid and reliable diagnostic regents against H5N1 virus. This regents would be helpful in controlling the circulation at the beginning of the outbreak and reducing the loss caused by the pandemic. The purpose of this research is to establish a panel of mAbs against HA of H5N1 virus for the antigenic analysis of H5N1 virus and then develop a series of rapid diagnostic regents for H5 influenza virus used in different circumstance.Fisrtly, with the help of phylogenetic analysis of H5N1 virus isolated from southeastern Asia recently, we know the evolution genesis of the HA1 gene in H5N1, then the high pathogenic strain“A/Ck/HK/Yu22/02”was chosen as the immunogen of H5 mAb preparation. At the same time the low pathogenic

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CLC: > Agricultural Sciences > Livestock, animal medicine,hunting,silkworm,bee > Animal Medicine ( Veterinary Medicine) > Veterinary clinical medicine > Veterinary diagnostics
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