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Objective: issues using taurine, vitamin B1, vitamin B2, calcium, iron and zinc group side, through the preparation process, the quality of research, Stability of animal memory function experiments, to get a safe, effective, stable and controllable quality , used to promote the development of children's brain tissue and the sound of the advanced features, prevention and treatment of learning and memory disorders caused due to lack of vitamins and minerals, memory loss and other symptoms, and to improve the mental development of children's products. Method: (1) to taste as index by single factor test screening accessories, based on the physical and chemical properties of the components, raw materials interaction test. Orthogonal design, taste, hardness, friability, disintegration as index, optimize the prescription and workmanship. (2) based on the results of product quality research to establish product quality standards. (3) In accordance with the guiding principles of Chinese Pharmacopoeia 2005 (Appendix XIX C) drug stability test, accelerated testing and long-term test, inspect preparations stability as an indicator character, identification, content, hardness and disintegration. (4) According to the \Results: (1) product selection xylitol, cocoa powder as a filler, and a flavoring agent, the protein sugar as a sweetener, polyvinylpyrrolidone as the binder, crosslinked polyvinylpyrrolidone as a disintegrant, the casein phosphopeptides as calcium and iron, zinc promote absorbers. The preparation process: raw materials mixed with efficient wet granulation machine 5min, slow to join the 60% ethanol solution of 8% polyvinylpyrrolidone, diced frequency of 20 Hz-30 Hz, high-speed 3s-5s granulation, at a temperature of 55 ° C - 65 ℃, the air intake frequency of 30Hz conditions, fluidized bed boil dry 15min-20min, pressure control tablet press 30KN, compression time tablet 3ms conditions. (2) the establishment of qualitative and quantitative methods of taurine, calcium, iron, zinc, vitamin B1, vitamin B2, the method by method validation compliance. Product measured, and the results are in line with the relevant standards and regulations, the establishment of a quality standard of the product. (3) test the products impact factor test, 6 months accelerated testing, the 24-month long-term test, the sample investigated indicators showed no obvious changes. (4) memory test showed that mice with different doses orally for 30 days, no significant changes in body weight of mice, step-down test, before and after the two water maze test results are positive. Conclusion: (1) screening reasonable prescription, the preferred process parameters have operability, controllability, and is suitable for industrial production. (2) product quality standards feasible, controllable product quality. (3) The product quality is stable. (4) the product has improved memory function.
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