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Clinical Research of the Nephron-sparing Surgery for Bilateral Renal Cell Carcinoma

Author: JiangPeng
Tutor: CaiSongLiang
School: Zhejiang University
Course: Surgery
Keywords: Bilateral Renal cell carcinoma Nephron sparing surgery
CLC: R737.11
Type: Master's thesis
Year: 2007
Downloads: 66
Quote: 0
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Abstract


Renal cell carcinoma is a common malignant tumors of the urinary tract , after the incidence of bladder tumor . Bilateral renal cell carcinoma are rare , accounting for only 1 % to 4% of renal tumors . Traditional principles of treatment underwent radical kidneys resection , postoperative patients have to rely on dialysis or a kidney transplant to sustain life . With the advances in diagnostic imaging technology , more early , sporadic renal tumors , nephron-sparing nephrectomy has also been unprecedented attention . Clinical studies abroad , nephron-sparing nephrectomy compared with the traditional radical nephrectomy patient survival , tumor recurrence rate had no significant difference in the post-operative renal function in patients . Domestic research is still small , and most of the case reported in the form or the sample size is small , but preliminary studies are considered safe and effective . Objective To evaluate the efficacy and safety of treatment of bilateral renal cell carcinoma reserved nephrectomy for renal units . Methods From January 1991 to December 2006 in our hospital were treated 23 cases of bilateral renal cell carcinoma , 14 males and 9 females . Aged 26 to 74 years , with an average of 51.6 years old . I reserves the nephron nephrectomy treatment of 19 cases of postoperative monitoring of hemoglobin , serum creatinine , blood urea nitrogen , urine protein . Follow - up after discharge review B , CT, chest X-ray , the assessment of tumor metastasis recurrence . The results of 23 patients with a mean follow-up of 3.4 years . 4 deaths , three of them were died of tumor metastasis , and 1 patient died of cerebral vascular accident . Patients with left upper lung metastasis , but still alive , one cases of the remnant kidney tumor recurrence , I had no recurrence and metastasis . Postoperative renal function may sustain life, and no significant change in serum creatinine , blood urea nitrogen , urine protein . The non starting side of the line radical nephrectomy and renal cell carcinoma , contralateral tumor from 7 months to 18 years . Kidneys after tumor resection longest survival time has reached 25 years . Conclusion bilateral kidney cancer is not a contraindication for surgery , if you take an active treatment measures , can still obtain satisfactory results . Nephron-sparing nephrectomy is the ideal method of treatment , the less its impact on renal function . Bilateral kidney cancer prognosis and unilateral renal cell carcinoma with tumor stage , grade , and whether the tumor is multiple .

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Urinary tumors > Kidney,renal pelvis tumor
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