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Preparation of Three New Kinds of Chitosan Derivatives and Their Antimicrobial Activity and Antioxidant Activity

Author: JiXia
Tutor: LiPengCheng
School: Graduate School , Chinese Academy of Sciences ( Institute of Oceanography )
Course: Marine Chemistry
Keywords: Preparation of chitosan derivatives Antibacterial activity Antioxidant activity
CLC: O631
Type: Master's thesis
Year: 2007
Downloads: 393
Quote: 0
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Abstract


This thesis is prepared three types of novel chitosan derivatives and its antibacterial and antioxidant activity screening study, specific results are as follows. By different molecular weight chitosan, the introduction of 1,3,5 - thiadiazine thione the first synthesis chitosan thiadiazin thione derivatives (N-2-amino benzene sulfonyl thiadiazin-thione - the chitosan (SATTCS), N-2-o-methyl-benzoth diazine thione - chitosan (TITTCS), N-2-o-chlorophenyl thiadiazin the thioketone - the chitosan (CITTCS)); by hydroxypropyl chitosan with different aldehydes was first synthesized hydroxypropyl chitosan Schiff base (hydroxypropyl chitosan schiff base (HHPCS), hydroxypropyl chitosan 5 - Chlorosalicylaldehyde Maki Schiff base (HCHPCS), the hydroxypropyl chitosan 5 - nitro salicylaldehyde Schiff base (HNHPCS), hydroxypropyl chitosan 5 - Bromosalicylaldehyde Schiff base (HBHPCS), the hydroxypropyl chitosan furfural Schiff alkali (FHPCS)); through different molecular weight chitosan with acetylated aromatic amine reaction is the first synthesis of the aromatic amine derivatives of chitosan acetyl the Neighborhood (the chitosan acetylaniline (ABCS), chitosan acetyl-chloroaniline (ACCS ), chitosan acetyl-fang, p-toluidine (TDCS) chitosan the the naphthylamine methacholine (MDACS)). IR, elemental analysis, and other methods of structural identification. Antimicrobial Activity of Staphylococcus aureus eight stacked bacteria, Escherichia coli, Pseudomonas aeruginosa, asparagus stem blight bacteria and some fungi: chitosan thiadiazine thione derivatives, chitosan acetyl aromatic amine derivative has a preferably inhibit bacterial activity, and the inhibitory effect of the derivatives of Staphylococcus aureus best. Different molecular weight, and antibacterial activity. The inhibitory effect SATTCS and LMANCS of bacteria best Antifungal activity, SATTCS and TDCS most significant. The antioxidant activity of screening results: Chitosan thiadiazine thione derivatives and hydroxypropyl chitosan Schiff base ability, has a strong scavenging hydroxyl radical scavenging ability of all superior Vc: chitosan thiadiazole the triazine thione derivative also has a strong reducing ability, wherein TITTCS reducing ability is stronger than Vc; Further, the low molecular weight chitosan thiadiazin-thione derivatives the ability to scavenge hydroxyl radicals and the reducing ability is slightly stronger than the molecular weight Chitosan thiadiazin thione derivatives. Prepared to work through this study three types of novel chitosan derivatives; biological activity studies have shown that: chitosan thiadiazine thione derivatives and chitosan acetyl aromatic amine derivatives have potential applications in bacteriostatic. The research has important implications for chitin-depth development and utilization of resources, promote the development of China's maritime drug.

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CLC: > Mathematical sciences and chemical > Chemistry > Polymer chemistry ( polymer ) > Polymer physics and physical chemistry of polymers
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