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Synthesis and Study of Multi-structure Compounds with 1,2,3-triazole

Author: MaZhiTao
Tutor: DongHengShan
School: Lanzhou University
Course: Organic Chemistry
Keywords: 1,2,3 - triazole (4E)-N- p-chlorophenyl - 5 - substituted phenyl - 2 - diazo -3 - oxo-4 - pentene amide N - ( 4 - chlorophenyl ) -5 - methyl-1 - substituted phenyl - 1H -1 , 2,3 - triazol-4 - carboxamide 5 - (5 - methyl - 1 - substituted aryl - 1H- 1 , 2,3 - triazol-4 - yl) -2 - amino-1 ,3,4 - thiadiazole 7 - methyl - 2 - ( 5 - methyl-1 - aryl - 1H-1 , 2,3 - triazol-4- yl )-5H-[1,3,4] thiadiazol- [3,2 - a] pyrimidin - 5 - one 7 - methyl - 2 - ( 5 - methyl-1 - aryl - 1H-1 , 2,3 - triaz
CLC: O626.26
Type: Master's thesis
Year: 2007
Downloads: 177
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Abstract


1,2,3 - triazole derivatives because of their wide range of biological activity has been since the discovery of highly favor of chemists . 1,2,3 - triazole ring , generally in the presence of acids , bases, oxidants can exist stably , but under certain conditions can carve ring isomerized diazonium amides , diazo carbonyl compound because of its reaction The diversity plays an important role in modern organic synthesis . This paper chloroaniline as a starting material , via a series of reaction of the important intermediate compound N- p-chlorophenyl group -2 - diazonium -3 - oxo - butanamide , and then re- synthesized by the reaction of the aryl amine and various substituted 10 N - ( 4 - chlorophenyl ) -5 - methyl-1 - substituted phenyl - 1H -1 , 2,3 - triazol-4 - carboxamide series substance . 1,2,3 - triazoles and 1,3,4 - thiadiazol oxazolo [ 3,2- a ] pyrimidine derivatives have been shown to have significant biological activity , in view of the different active heterocyclic heterocyclic nuclear aggregation can significantly improve the biological activity of the compound in the same molecule , we envisage a mixture of 1,2,3 - triazole group is introduced to the thiadiazole and pyrimidine precursor . In the field of study of the pyrimidine compound in order to obtain a higher activity and expand thiadiazolo synthesized 7 5 - (5 - methyl-1 - substituted aryl -1H-1, 2,3 - triazol -4 - yl) -2 - amino-1 ,3,4 - thiadiazole intermediates and a 7 - methyl-2 - ( 5 - methyl-1 - aryl - 1H - 1 , 2,3 - triazol - 4 yl ) -5H - [ 1,3,4 ] thia- oxadiazol- [3,2-a] pyrimidin - 5 - one final product . Xanthene derivatives and pyrrolo [ 3,4 - c ] pyrrole alkanone derivatives have relatively good fluorescent properties we try the triazole ring and the body and is connected to the fluorophore , in order to obtain a novel class of highly fluorescent quantum yield and broad application prospects compound . Study and discuss the synthesis of fluorescent compounds containing 1,2,3 - triazolyl and the reasons for the failure . The structure of all new compounds were characterized by HNMR, MS, IR spectrum

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CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Heterocyclic compounds > Containing five pairs or more different atoms of heterocyclic > Three azoles ( triazole )
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