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Synthesis of Pyrrolo-and Pyrrolidino[1,2-a] Quinolin-1-one via Intermolecular [4+2] Reactions of N-Acyliminium Cations with Olefins

Author: HuangLiMin
Tutor: ZhangZuo
School: Lanzhou University
Course: Organic Chemistry
Keywords: Lanzhou University Cyclization reaction Carbocation Thesis Acid imine Cycloaddition reaction Intermolecular Imide Pyrrolidine Olefin
CLC: O626
Type: Master's thesis
Year: 2007
Downloads: 45
Quote: 0
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Abstract


This paper introduces the research work between the N- imide positive ions and olefin molecules [ 42 ] reaction . (1) 5 - hydroxy-1 - aryl - pyrrole-2 - one , or 5 - hydroxy-1 - aryl - pyrrolidine-2 - keto The BF were the 3 · OEt 2 < / sub> catalyzed the N- imide ion with an olefin , such as styrene, α- methyl styrene , propenyl anisole , ethyl vinyl ether , indene, [ 42 ] cycloaddition reaction. Established a synthetic pyrrole or pyrrolidine and [1,2-a] quinolinone simple method . ( 2) Try the positive ions of the N- imide with an olefin obtained by chiral hydroxy lactam [ 42 ] cycloaddition reaction , stereoselective synthesis pyrrolidine and [ 1,2 - a ] quinoline ketone Experimental , did not achieve the desired results . (3) attempts to ω-hydroxy- lactam substrate, iso- indol-1 - one and 1,3 - dicarbonyl -based compounds such as 2,3 - dihydro-3 - hydroxy-2 - aryl condensation reaction .

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