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The Study of the Mechanism of PARP-1 Activity Involved in the Transcriptional Regulation of NF-κB

Author: LiuLinLin
Tutor: BaXueQing
School: Northeast Normal University
Course: Genetics
Keywords: PARP-1 LPS NF-κB transcriptional regulation
CLC: R363
Type: Master's thesis
Year: 2011
Downloads: 54
Quote: 0
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Abstract


Poly(ADP-ribose) polymerase (PARP)-1 is an enzyme which is particularly abundant in cell nucleus. In response to DNA-strand breaks,it catalyze the transfer of ADP-ribose units from NAD+ to substrate proteins. PARP-1 plays a key role in the maintenance of genomic integrity,control of cell cycles by physiological stimulation. Recent studies revealed that gene transcription regulated by PARP-1 involved in many cellular processes. The microbial infection triggers the producing of ROS,thereby,impairs DNA. The TLR family senses the molecular signatures of microbial pathogens,and plays a fundamental role in innate immune responses. Many pro-inflammatory gene transcription regulations are associated with activation of NF-κB in immune responses. However,the mechanism of PARP-1 activation and how PARP-1 regulates gene transcription in inflammation disorders are unclear. Our work aims to identify whether PARP-1 can be activated in Ana-1 macrophages by the stimulation of LPS,the ligand of TLR4. How LPS induced the activation of PARP-1 to participate the regulation of gene transcription? Whether PARP-1 and NF-κB are coactivtors in transcriptional regulation?The results will help us to further understand the mechanism of transcriptional regulation induced by PARP-1,and discover other cellular signaling pathways in inflammation processes.

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