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Objective: To investigate the drug-eluting stent joint safety of anticoagulation before and after implantation . Methods : 36 patients, percutaneous transluminal coronary angioplasty and drug -eluting stent implantation , respectively, on admission , preoperative and postoperative one day , three days , five days in January , March , at each time point blood on the semi-automatic coagulation analyzer ACL-9000 by coagulation ( beads ) principle coagulation parameters were measured : prothrombin time ( PT ) and activated partial thromboplastin time (APTT) and plasma fibrinogen ( FIB), to observe the changes of these indicators as well as preoperative and postoperative joint use of anticoagulant drugs during treatment related complications observed differences in coagulation indicators compare bleeding and control groups . Results: In the drug-eluting stent implantation preoperative , intraoperative , postoperative joint use of anticoagulant therapy during at each point in time , coagulation parameters PT , APTT , INR was no significant difference (p> 0.05), bleeding group with the control group of the coagulation parameters PT , APTT , INR was no difference ( p > 0.05 ) , plasma fibrinogen (FIB) content in intraoperative levels gradually increased after day the highest values ??( p <0.01 ) , began to decline after three days , but still higher than the admission and before surgery (p <0.05), after January, returned to normal levels . 9 cases of non - fatal bleeding complications during clinical observation and treatment of complications , and 36 patients , including two cases of subcutaneous ecchymosis ; 2 cases of hematuria ; 3 cases of bleeding gums ; nose bleeding in 1 case ; eyelid bleeding in 1 case ; follow-up three months no coronary thrombosis . Conclusion : 1 . FIB elevated ACS induced hypercoagulable state , the mechanism may be : FIB acute phase reaction signs of inflammation sensitive tissue damage or inflammation and stress , the increased synthesis of fibrinogen . 2. PT, APTT, INR in the preoperative , intraoperative , postoperative combined PCI, anticoagulation guiding significance ; 3. The above indicators can not be used for safety monitoring of PCI operation combined with anticoagulant . 4. PCI, routine use of aspirin , clopidogrel , low molecular weight heparin anticoagulant therapy is safe and effective the existing dose not affect bleeding events .
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