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Perimenopausal and postmenopausal women with ovarian dysfunction, estrogen levels decline, often body mass increase caused by the body is bloated and obesity, clinical commonly used hormone replacement therapy in perimenopausal disorders can be caused a number of side effects, White Shao as one of the drugs commonly used, but has yet to see how perimenopausal and postmenopausal women obesity reported. The purpose of this experimental study: ① establish animal models to be obese menopausal women by ovariectomy; (2) to explore the laws of energy metabolism of ovariectomized rats; ③ explore peony root decoction on ovariectomized rats obesity suppression mechanism. Experimental selection of healthy female SD rats, body mass 220.7 ± 3.0g, were randomly divided into sham group (SHAM) 8 only surgery group (OVX) 8 only white peony group the (OVX RPA) 7 Zhi, pre-operative groups large mice weighed 12 hours of fasting, drinking water is not limited to, ketamine 100mg/kg intraperitoneal injection of anesthesia, the surgery group, white peony root rats bilateral ovariectomy, sham group repeated bilateral ovariectomy step, not removal of the ovaries, but ovariectomy equal-sized fat around the block, after surgery, the rats eat normally water, white peony group starting from the first day to give incorporation peony root water decoction of rats drinking water natural drinking by rats, the concentration from 1% began to impact the day rats normal food intake and normal water intake standards within five days of the concentration gradually added to 12%, to 55 days to maintain the concentration of food intake is not limited. Every five days measuring each rat quality recorded at the same time each rat daily average food intake and the amount of drinking water for 55 consecutive days. Calculate the average daily food intake and water intake of each rat. The end of 55 days, 12 hours of fasting, femoral artery blood serum glucose, serum estradiol, insulin, alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, high-density lipoprotein, LDL, total antioxidant capacity, malondialdehyde, leptin, interleukin-6, tumor necrosis factor-α. After the animals were killed, an accurate determination of the length, tail length, calculated Lee's index, all data (?) ± s single-factor analysis of variance, multiple sets of data. The experimental results are as follows: 1. Body weight compared with the sham group, the surgical group, Lee's index, average daily per rat food intake significantly increased serum alanine aminotransferase, aspartate aminotransferase, HDL, LDL, triglycerides, total cholesterol , malondialdehyde, leptin, tumor necrosis factor-α levels were significantly higher serum estradiol levels were significantly decreased. 2. Surgery group, drinking white peony peony root water decoction rats significantly reduced in ovariectomized rats caused by food intake, body weight, Lee's index increased serum triglycerides, malondialdehyde, leptin , tumor necrosis factor-α levels rise. This study showed that: peony root water decoction can significantly inhibit food intake in ovariectomized rats affect feeding related to regulating hormone levels, thereby inhibiting the cause of obesity and ovariectomized, white peony root can improve lipid metabolism, remove the body Too many free radicals, improve the body's antioxidant capacity.
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