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Intervention Effects of Aerobic Exercise and Soy Polypeptide on the Informing of High-fat-diet-induced Insulin Resistance in SD Rats and Its Mechanisms

Author: ZhangMeiLing
Tutor: JinQiGuan
School: Yangzhou University
Course: Human Movement Science
Keywords: Aerobic exercise Soybean peptides Insulin Resistance High-fat diet Lipids Insulin sensitivity Tumor necrosis factor -α Interleukin-6
CLC: G804.2
Type: Master's thesis
Year: 2007
Downloads: 210
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Abstract


Experimental purposes: to explore sports training and soybean peptide (SPI) on the high-fat diet rats insulin resistance (IR) formed in rats and its mechanism, and the interaction of sports training and supplement SPI IR formed intervention role. Experimental Methods: Rats were divided into five groups: normal diet control group (C group), high-fat diet group (HF), high-fat diet and exercise group (HE group), high-fat diet soybean peptide group (HS group), high The fat diet and exercise to Training the soybean peptide Group (HSE group). Rats was measured daily food intake were measured weekly rat body length and weight. The exercise program is 10 weeks 60min without load swimming, six days a week. SPI gavage dose 500mg/kgBW. Experiment eight weeks when the oral glucose tolerance test (OGTT), and the end of the experiment, fasting plasma glucose (FPG), fasting insulin (FINS), triglyceride (TG), total cholesterol (TC), serum levels of tumor necrosis factor-α ( TNF-α) and interleukin -6 (IL-6), C peptide (CP) and other indicators, and calculated insulin sensitivity index (ISI), homeostasis model assessment-IR index (HOMA-IR), Lee index (Lees,) to help determine the formation and movement of the IR and SPI IR intervention. Results: (1) compared with C rats, HF rats FINS, FPG, HOMA-IR was significantly increased (P <0.05, P <0.01), while the ISI was significantly lower (P <0.01); OGTT test that HF ??rats fasting and 2h postprandial blood glucose were significantly higher in group C (P <0.01, P <0.05); HF group serum TG, TC and of serum IL-6 levels were significantly increased (P <0.05 , P <0.01), HF serum TNF-α levels in group C showed no significant difference, but the increased range up to 25%. HF serum CP content compared with the C group, no significant difference. (2) by two-way ANOVA, sports training or supplement SPI fat diet induced rat IR formation has a significant role in the intervention. Formed in the high-fat diet induced IR sports training, enables high-fat diet rats FPG, FINS, HOMA-IR index was significantly reduced, and the ISI was significantly higher (P <0.05, P <0.01); while The high-fat diet serum TG, TC, TNF-α and IL-6, and fasting and postprandial 2h plasma glucose was significantly lower (P <0.05, P <0.01). Formed in the high-fat diet induced IR supplement SPI, enables high-fat diet rats FINS, HOMA-IR significantly reduced, ISI was significantly higher (P <0.01), although reducing FPG content, but no significant differences; and high-fat diet serum TG, TC, TNF-α and IL-6 levels and fasting and 2h postprandial blood glucose was significantly lower (P <0.05, P <0.01). Sports training or supplement SPI enables high-fat diet serum CP decreased, but there was no significant difference. (3) by two-way ANOVA, sports training at the same time joint supplement SPI allows high-fat diet rats FPG, FINS, HOMA-IR decreased, ISI increased, but there was no significant difference. OGTT experiment, enables high-fat diet rats fasting and 2h postprandial blood glucose were significantly lower (P <0.01); sports training joint supplement SPI allows high-fat diet serum TG, TC, TNF-α and significantly reduced IL-6 levels, and serum CP content was significantly higher (P <0.05, P <0.01). Experimental conclusions: (1) a 10-week high-fat diet can make rats FPG, FINS, HOMA-IR index significantly increased the ISI index significantly reduced to 10-week high-fat diet can induce the formation of rat IR. (2) in the high-fat diet induced IR formed at the same time, to 60min 10 weeks exercise training or supplement the SPI can significantly reduce the high-fat diet rats FPG, FINS, HOMA-IR index, improving ISI index, which can show the movement training or supplement SPI can significantly prevent the IR the formation of high-fat diet rats. Moreover, exercise training combined SPI added having a promoting effect on the prevention of the IR the formation of high-fat diet rats to a certain extent. (3) high-fat diet induced IR formation mechanism and high-fat diet rats elevated blood lipids, reduced sensitivity of peripheral Ins R, and the related increase in TNF-α and IL-6 secretion. And exercise training or supplement SPI can prevent the formation of IR by improving lipid metabolism, enhance the sensitivity of peripheral tissues Ins R and inhibition of TNF-α and IL-6 secretion.

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