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Left ventricular hypertrophy (Left ventricular hypertrophy, LVH) is one of the major complications of hypertension , is caused by an independent risk factor for cardiovascular disease . With the development of LVH , also increasing the probability of occurrence of stroke, myocardial infarction , angina , congestive heart failure and renal failure . Seeking the ideal good curative effects and side effects of both buck and can effectively reverse LVH drug is an important goal of the current study of the treatment of hypertension . The pathogenesis of hypertensive LVH is more complex , researchers myocardial tissue protein kinase C (PKC) is involved in the occurrence of hypertension , the formation and development of hypertension LVH is its myocardial tissue PKC high , expressed . This issue through Goldblott renal hypertensive rats (G-RHR) left ventricular hypertrophy model study on the pathological changes in blood pressure , left ventricular mass index , cardiac cell morphology parameters of myocardial tissue and myocardial cell expression of PKC the therapeutic effect of traditional Chinese medicine compound heart Shukang the self to a conclusion . The experimental results show that : (1) the heart Shukang have significant antihypertensive effect . (2) the heart Shukang able to reduce left ventricular mass index , reduce the volume of the myocardial cells , inhibit fibrosis in interstitial cells . (3 ) by light microscopy , electron microscopy observation and immunohistochemistry confirmed : heart Shukang able to reduce the expression of PKC in cardiac tissue , which play the role of mitigation and reversal of LVH . In summary , The Chinese medicine compound heart Shukang the buck and mitigation and reversal of LVH were significantly .
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