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The Effect on the Expression of IRS-1 and p-ERK on Insulin Resistance of Trophoblastic Cell with Tanshinone

Author: XingJunXiu
Tutor: WuXiaoKe
School: Heilongjiang University of Traditional Chinese Medicine
Course: Chinese Gynecology
Keywords: Insulin Resistance Trophoblastic Tanshinone
CLC: R285.5
Type: Master's thesis
Year: 2007
Downloads: 93
Quote: 0
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Abstract


Objective: To study drug intervention group trophoblast cells , insulin receptor substrate -1 (IRS-1) and mitogen-activated protein kinase (MAPK) protein and its relationship with gestational hypertension . Methods : ( 1) in vitro culture of human chorionic trophoblast - induced insulin resistance fertile diffuse penicillin role in trophoblastic ; (2) Western blot detection of insulin receptor substrate -1 (IRS-1) and phosphorylation extracellular signal-regulated kinase (p-ERK) changes in the normal group , the solvent group , insulin resistance , tanshinone group and metformin group . Results: (1) under the microscope the visible cells showed polygonal , cell tile growth syncytiotrophoblast formed after cell fusion ; (2) when the cell insulin resistance , IRS- 1 GSR to 0.6857 , compared with normal control group GSR ( 0.5417 ) increased by 26.58% , adding drugs to improve insulin resistance tanshinone group GSR (0.5890) 16.42% , metformin group the GSR (0.6429) of 6.66% ; ( 3 ) in the fertile diffuse penicillin - induced insulin resistance p - the GSR of ERK was 1.7 , higher than the normal control group GSR (1.0833) 56.93% ; tanshinone group adding drugs to improve insulin resistance GSR (1.3425) than resistance group decreased by 26.63% , the metformin group GSR (1.5429 ) than resistance group decreased by 10.18% . Conclusion: the Tanshinone of IRS-1 , insulin resistance to improve the level of the superior to metformin ; role of Tanshinone and metformin p-ERK , can improve their level of insulin resistance .

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