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Effect of Electro-Nape-Acupuncture on Aquaporin4 and Water Content of Brain after Brain Ischemic Injury in Rats

Author: JiangJianLing
Tutor: GaoWeiBin
School: Heilongjiang University of Traditional Chinese Medicine
Course: Acupuncture and Massage
Keywords: Cerebral ischemia Cerebral edema Brain water content AQP4 Electrical items needle
CLC: R245.97
Type: Master's thesis
Year: 2007
Downloads: 86
Quote: 0
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Abstract


Objective: To observe the electrical items needle and electricity for the aquaporin 4 adult male rats after cerebral ischemia and brain water content , and the role of the difference between the the power projects needle and EA to study electrical items needle treatment of rat brain the possible mechanisms of ischemic brain edema . Methods : The rats were randomly divided into four groups: sham operation group, model group , the power projects acupuncture group , electro-acupuncture group ; cerebral artery suture method in rat focal cerebral ischemia model ( MC AO ) ; after the modeling, 6h, 1d, 2d, 3d, 5d killed drawn ; using neurological score of rats neurological signs ; wet and dry weight measurement of the water content of the rat brain ; HE staining rat brain tissue pathological changes ; immunohistochemistry of rats after ischemia aquaporin- 4 ( AQP4 ) expression changes , to evaluate the electrical items needles and electrical cerebral ischemia and brain edema and electrical items needle EA treatment effect. Results: (1) power projects in the acupuncture group and EA group rats neurological signs in the postoperative 3d and 5d, compared with the model group significantly reduced , there is a significant difference ( P < 0.05 ) by the statistical test . (2) cerebral ischemia in brain tissue with varying degrees of pathological changes , electrical items acupuncture group and EA group compared with model group , the infarct size is small , light edema , 3d and 5d when there are a large number of glial cell proliferation and newborn capillaries. Which electrical items acupuncture group than the EA group . (3 ) cerebral ischemia and cerebral water content was significantly increased, electrical items acupuncture group and EA group and the model group , 3d and 5d brain water content was significantly reduced by the statistical test was a significant difference ( P < 0.01 ) . Electrical items acupuncture group and EA group , 3d and 5d significant difference ( P < 0.05 ) . (4 ) cerebral ischemia different time points after AQP4 expression was significantly increased , 3D and reached the peak . Electrical items acupuncture group and EA group compared with model group , 3d and 5d positive cells than significant difference ( P < 0.05 ) . Power projects acupuncture group and EA group , expressed in 3d and 5d significant difference ( P < 0.05 ) . Conclusion: (1) pin power projects can promote the neurological signs of recovery after cerebral ischemia ; (2) electrical items have a protective effect against ischemic brain tissue in rats ; (3) pin power projects can reduce cerebral ischemia brain water content , and superior to the EA ; (4) pin power projects can inhibit the expression of AQP4 after cerebral ischemia , and better than EA .

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