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Objective : To observe the joint Salvia treatment of chronic obstructive pulmonary disease, acute exacerbation of (AECOPD) serum MMP -9 , TIMP -1 impact . Methods: 60 patients with acute exacerbation of moderate to severe (AECOPD) patients and 30 healthy group , 60 patients with COPD , divided into A paired into groups according to age, gender , disease duration , COPD classification , CPIS score 1:1 group ( the Salvia intervention group ) 30 cases , 30 cases of 30 cases of B group ( conventional treatment group ) and group C ( healthy group ) , A , group B underwent the COPD conventional treatment course of 7-10 days , the A group in addition to conventional therapy layman Salvia powder for injection 800mg intravenous infusion , once daily treatment for 7-10 days . A and B patients with the treatment of the acute phase and after treatment with stable and Group C are enzyme-linked immunosorbent assay were used to detect the serum MMP-9 (pg / ml), TIMP-1 values ??( pg / ml ) , MMP-9/TIMP -1 ratio . Results : A , B serum acute phase of the MMP-9 level was significantly higher than the stabilization period ( P lt; 0.01 ) , the stabilization period is also higher than the C group ( P lt ; 0.01 ) in group A and group B , A , group B acute phase serum MMP-9 level was no statistical difference ( P gt ; 0.05) , A , B group remission period of MMP-9 levels in group A was lower than that in B group ( P lt ; 0.01) , A , B serum TIMP-1 levels The acute phase was significantly higher than the stabilization period ( P lt; 0.01 ) , the stabilization period is also higher than the C group ( P lt; 0.01 ) , group A and group B , two sets of acute phase remission phase serum TIMP-1 levels were not statistics differences between ( P gt; 0.05 ) . A , group B serum MMP-9/TIMP-1 levels of acute phase was significantly higher than the stabilization period ( P lt; 0.01 ) , the stabilization period is also higher than that in group C ( P lt; 0.01 ) , the A group and B group , two groups acute phase remission period serum MMP-9/T1MP-1 level , there was no significant difference (P gt ; 0.05 ) . Conclusion : MMP-9 involved in the airway inflammatory process of COPD , TIMP-1 involved in the COPD airway repair process MMP-9/TIMP-1 imbalance exists in the pathogenesis of COPD , Salvia may inhibit matrix metalloproteinase thus , a protective and therapeutic effect on patients with COPD .
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