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The background of coronary heart disease (coronary heart disease, CHD) has become one of the serious harm to human health, today the most common cardiovascular diseases that affect people's quality of life, showed an increasing trend in our country. Acute coronary syndrome (acute coronary syndromes, ACS) including unstable angina (unstableangina pectoris, UAP), acute myocardial infarction (acute myocardial infarction, AMI) and sudden cardiac death, including a group of serious harm. coronary heart disease critical disease. Studies have shown the vulnerability of atherosclerotic plaque in the coronary arteries rupture and secondary thrombosis is the main pathogenesis of ACS. However, lead to plaque rupture, thrombosis initiating mechanism is not entirely clear. Whether these pathophysiological process unique markers can predict the occurrence of acute events? These factors to determine the degree of coronary stenosis does it make sense? Till now there is not a clear conclusion. C-reactive protein (C reactiveprotein, CRP) are considered to be important biological markers of inflammation in the reaction process. Studies have shown that elevated CRP is a strong risk factor for acute myocardial infarction and other acute coronary events, and evaluation of unstable angina prognosis plasma hsCRP (high sensitivityc-reative protein) with high sensitivity representative and accuracy inflammatory cytokines. Von Willebrand factor (von Willebrand Factor, vWF) is a glycoprotein of the human body hemostasis and thrombosis, plasma vWF synthesized by endothelial cells, stored in the endothelial cells weibel-pallade small body, when endothelial released into the blood cell damage, has mediated platelet adhesion by regulating coagulation factor Ⅷ promote thrombus formation function. Important factor of the indicators as the the specificity reflects vascular endothelial cell damage and participate in the process of thrombosis, vWF and coronary heart disease, the relationship to get more and more understanding. By detecting different types of patients with coronary artery disease and normal control group blood hs-CRP, vWF level, to explore their relationship with the severity of coronary heart disease and stability, and to study its possible mechanism of action, and to provide a theoretical basis for clinical intervention. Methods 87 cases of patients with coronary heart disease, according to the diagnostic criteria divided into three groups: 27 patients with stable angina pectoris (SAP), unstable angina (UAP) group of 42 patients, group of 18 patients with acute myocardial infarction (AMI). Select a control group of 25 patients. The respective serum hsCRP of vWF concentration, Judkins method of all study participants underwent coronary angiography results Gensini score system evaluation of coronary artery disease severity, simultaneous determination of various conventional biochemical tests was measured by enzyme-linked immunosorbent assay (ELISA). Results 1. Between coronary heart disease each sub-group and the control group in the sex ratio, age, body mass index (BMI), smoking history, hypertension, diabetes, family history, cholesterol and other clinical data showed no significant difference (P> 0.05). The 2.UAP and AMI groups of hsCRP, vWF concentration (5.61 ± 0.85 mg / L, 118.68 ± 22.72% and 7.19 ± 0.82mg / L, 134 ± 22.97%) was significantly higher than the SAP group (1.83 ± 0.54 mg / L, 84.69 ± 20.73%) and normal control group (1.21 ± 0.60mg / L, 69.12 ± 15.46%) (P <0.05), SAP group and normal control group between the two experimental indicators compare the difference was not statistically significant (P> 0.05). In the UAP group and AMI group, plasma hsCRP of vWF in coronary stenosis integral into positive correlation, the correlation coefficient (r) in the UAP group were 0.579 (P = 0.021), 0.485 (P = 0.027), in patients with AMI were 0.658 (P = 0.014), 0.694 (P = 0.009). SAP group and two experimental parameters were not related, the correlation coefficient (r) were 0.324 (P = 0.212), 0.375 (P = 0.186). Conclusions blood hsCRP, vWF levels in patients with acute coronary syndrome was significantly higher than that of patients with stable angina pectoris and normal. 2 blood hsCRP, vWF levels of can prompt unstable coronary artery disease in patients with coronary artery disease. 3. Patients with acute coronary syndrome blood hsCRP and the vWF in may reflect the degree of coronary artery disease.
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