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Chili pepper extract is rheumatism ointment, borneol, menthol as an active ingredient paste, with blood analgesic effect, is widely used in joint pain, the treatment of rheumatism. Its now closed Ministry of Health standards set out in the traditional Chinese medicine prescription preparations ninth book. The topic of pepper extract preparation process was optimized and validated, combined with the nature of pepper extract to polyacrylic acid / sodium polyacrylate copolymer pressure-sensitive adhesive matrix material, through the tackifier, excipients, and moisturizing optimization agent complex, prepared with biocompatible Bab pepper paste rheumatism. In accordance with the Chinese Pharmacopoeia (2005 edition) requirements, chili paste rheumatism Babu conducted a systematic study to ensure that safe and effective chili paste rheumatism Babu, quality control, good stability. The main results are as follows: (1) to capsaicin extraction efficiency evaluation, study refluxed pepper capsaicin extraction process conditions were investigated extraction temperature, ethanol concentration on the extraction efficiency, according to the single-factor test, the L9 (34) orthogonal experiment screened pepper Capsaicin optimum extraction; to pepper extract yield, extract the capsaicin content, doing paste yield index to determine the stability of the pepper extract preparation and different habitats capsaicin pepper, pepper extract properties were studied. (2) to tack, appearance and skin conformability investigated as evaluation indexes for prescription optimization to determine the optimal prescription. Optimal prescription is: polyacrylic acid / sodium polyacrylate copolymer is 5% to 0.15% cross-linking agent, a tackifier -1 2% 2% tackifier -2, -3 to 3% of a tackifier , pH adjusting agent was 0.3%, the crosslinking agent is adjusted 0.05% to 1% excipient, 30% of humectant; pepper paste rheumatism Babu skin biocompatibility study results show that Bob pepper paste with rheumatoid good moisture permeability and biocompatibility of the skin, but with a slight skin irritation; pepper paste Babu of rheumatoid factor test results show that light, heat can lose some pepper paste rheumatoid Bob moisture, greater influence to the appearance and adhesiveness of the high water content of humidity, adhesion and appearance affected. (3) establish a chili paste in rheumatoid Babu borneol, menthol by TLC method, homemade samples borneol, menthol were identified; established capsaicin capsicum rheumatism plasters Babu HPLC determination chromatography (HPLC) method, the concentration of capsaicin 20.32 ~ 203.2μg · mL-1 good linear relationship, solution stability, high precision, good repeatability; small test batches for homemade capsaicin content samples containing Determination cream; conduct trials investigated in vitro transdermal capsaicin capsicum rheumatism plasters Babu vitro transdermal, the results showed that: capsaicin in chili paste rheumatism Babu for 24 h was higher than commercially available through rubber ointment.
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