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Blood pressure level sprays by Prunella, chrysanthemum, peony, magnolia, cinnamon root, angelica, mint set of square preparation made for the treatment of hypertension. Early experimental and clinical studies found that blood pressure level sprays 3g / (crude drug) will be able to play a good antihypertensive effect, and produce good antihypertensive effect What is the reason? On the one hand it may be due to nasal unique physical structure not only to avoid the first-pass effect of oral administration, but also through the passage between the nose and the brain, drugs can also bypass the blood-brain barrier; On the other hand the interaction between a variety of chemical constituents in the compound of the blood pressure level, and change the ADME procedure of the active ingredient. Advantages exist for nasal administration has been confirmed. Speculated to demonstrate the latter, the subject first start from the absorption point of view, the use of rats intranasal absorption of the main active ingredient in the recirculating perfusion Nasal blood pressure level compound, designed to determine the blood pressure level spray The main active ingredient the intranasal absorption characteristics provide a theoretical basis for the screening of blood pressure level spray formulation selection and accessories. In this paper, a review of the literature on the chemical constituents and pharmacological effects of the compound herbs, to determine the blood pressure level compound closely related to buck ingredients, were Paeoniflorin, Paeonol, cinnamic acid, chlorogenic acid, ferulic acid and establish a HPLC method for the determination of these five ingredients. This selection of the absorption of active ingredient nasal mucosa in the the body nasal cavity recirculating perfusion in rats, currently used esophageal intubation difficult experimental operation, the drawbacks of the low success rate, it will esophageal intubation changed to endotracheal intubation. (Rhinitis water drops through three model drug, furosemide Ma nasal drops, blood pressure level sprays) improved nasal circulation perfusion verify the feasibility to determine the feasibility of improved test methods. The nasal absorption of the main active ingredient in the improved nasal cavity in the body on the basis of the recirculating perfusion study the characteristics, including the osmotic pressure, pH value, flow rate, the volume of administration, the administration concentration. In order to determine the optimal experimental conditions for a flow rate of 1.8ml/min, administration volume of 10mL, Paeonol, cinnamic acid, chlorogenic acid, ferulic acid intranasal absorption are passive diffusion and absorption. The same time found that absorption Paeoniflorin situation is not ideal, but the compound is well absorbed. The paeoniflorin poor absorption phenomenon, paeonol, cinnamic acid, chlorogenic acid, of Ferulic Acid Paeoniflorin absorb impact, as well as the role of the volatile oil absorption. The results showed that the mixture the nasal mucosa Paeoniflorin absorption certain role, but absorption with the preparation, there is a certain gap. The addition of volatile oil absorption has been further improved. Accessories be added in the preparation of drug absorption impact, this paper were investigated after adding accessories Paeoniflorin intranasal absorption. The results showed that chitosan and hydroxypropyl beta cyclodextrin strongest absorption enhancement can be used as pharmaceutical excipients of the blood pressure level sprays.
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