Dissertation > Excellent graduate degree dissertation topics show

Study on the Changes of vWF and GMP-140 in Plasma of Patients with Budd-Chiari Syndrome

Author: LiLinPeng
Tutor: WangGuangTian；XueHuanZhou
School: Zhengzhou University
Course: General Surgery
Keywords: Budd-Chiari syndrome von Willebrand factor (vWF) Granule membrane protein-140 (GMP-140)
CLC: R657.3
Type: Master's thesis
Year: 2004
Downloads: 61
Quote: 0
Read: Download Dissertation

Abstract


Budd-Chiari syndrome (B-CS) refers to posthepatic portal hypertension (PHT) and/or inferior vena cava hypertension caused by obstruction in outlet of major hepatic veins and/or posthepatic inferior vena cava. Though many kinds of causes about B-CS have been reported, they are uncompleted and indefinite. So the investigation of the etiology in B-CS is valuable and important especially to the clinical diagnosis and treatment. In recent years, many physicians have accepted the theory that the B-CS is not inborn but the sequels from the thrombosis. The hypercoagulation of patients with B-CS caused by many different causes, such as hyper-erythropoietin, colony-forming units erythroid and myoloproliferative disorder so on. And during the research of the thrombosis many physicians draw a conclusion that the increased quantity of vWF and GMP-140 is one of the most prevalent factors, which cause vein thrombosis. vWF is the specific molecule symbol of injury vascular endothelium cell and GMP-140 is the specific symbol of activation and release of platelets. But there have been few reports about the relation between the B-CS and theincreased quantity of vWF and GMP-140 now. To explore the causes of hypercoagulation and give theoretical support in clinical diagnosis and treatment, vWF and GMP-140 in patients with B-CS were investigated in this study.Materials and methods:60 patients in B-CS group including 42 patients (12~56years) with thrombus type B-CS (31 males and 11 females with the mean age of 29.6?.9 years), and 18 patients (26~49years) with membrane type B-CS (8 males and 10 females with mean age of 32.6?.2 years) were all diagnosed definitely with Color Doppler sonography and/or inferior vena cavography(IVCG) from June,2002 to Oct 2003 in Henan Provincial People’s Hospital. In control group, there were 30 healthy persons (16~65years) including 16 males and 14 females, with mean age of 35.9?.8 years. Both vWF and GMP-140 were got form the vena blood plasma before and 2 weeks after the operation in B-CS group and during the health condition test in control group. The quantity of vWF and GMP-140 was measured with enzyme linked immunosorbent assay. And in B-CS group, the platelet was got from the vena blood and the number was measured with the normal method.Results:1. Before operation, the quantity of vWF and GMP-140 was (251.67 118.39)% and 87.92?4.47ng/mL in patients with B-CS, (256.73?124.49)% and 88.60?5.04 ng/mL in thrombus type B-CS, (239.85?03.82)%, and 86.32?6.46 ng/mL in membrane type B-CS, (112.25?6.61), and 24.90?.31 ng/mL in the controls. There was significant difference between B-CS group and control group (P0.01). The different quantity of vWF and GMP-140 between the thrombus type B-CS and the membrane type B-CS was not significant (P>0.05).2. Before operation, in patients with thrombus type B-CS, the number of platelet was (91 3 4) 109, and there was no significant correlation between the number of platelet and the quantity of vWF and GMP-140 (r=-0.1641 and -0.0369, P>0.05 ) . Therefore it is suggested that the injury of vascular endothelium and stimulation of platelet be the important factor in the formation of B-CS.3. Two weeks after operation, in patients with thrombus type B-CS, the quantity of vWF and GMP-140 was (248.36+113.43) % and 81.73?7.76ng/mL. There was no significant difference between the pre-operation and post-operation in patients with thrombus type B-CS (P>0.05). Therefore it is suggested that the operation should not change the hypercoagulation in patients with thrombus type B-CS. In patients with membrane type B-CS, the quantity of vWF and GMP-140 was (119.76?7.52) % and 41.33?2.30ng/mL.There was significant difference between the pre-operation and post-operation in patients with membrane type B-CS (P>0.05). Therefore it is suggested that the operation should change the hypercoagulation in patients with membrane type B-CS.Conclusions:1. Before operation, the patients with B-CS have higher quantity of vWF and GMP-140 than the controls, which indicate th

Related Dissertations

  1. A Study on the Content and Signiticance of Color Doppler Ultrasonography of Budd-Chiari Syndrome before Interventional Therapy,R445.1
  2. Budd-Chiari Syndrome Applied Anatomy of Inferior Vena Cava, Hepatic Vein and Portal Vein,R657.3
  3. Discuss Relationships between Budd-Chiari Syndrome and Living Environment High-Iodine, Dietary Habits,R575
  4. Study of Coronary Angiographic Features and Endothelial Function in Patients with Coronary Heart Disease and Hyperglycemia,R541.4
  5. Correlation of Serum Levels of hsCRP and vWF to the Degree and Stability of Coronary Artery Lesion in Patients with Coronary Heart Disease,R541.4
  6. Experimental Research on Smooth Muscle Cell Proliferation and Intimal Hyperplasia in Autogenous Vein Graft,R654.3
  7. Morphology of Pathologic Membrane in Inferior Vena Cava and Screening for Its Correlate Gene in Budd-Chiari Syndrome,R654.2
  8. The Study of Etiology of Budd-Chiari Syndrome,R575
  9. Budd-Chiari Syndrome: Pathological Features of Liver and Analysis of Related Factors,R575
  10. The Interventional Therapy of Budd-Chiari Syndrome,R575
  11. Correlation between the Polymorphism of vWF Gene Thr789Ala and the Level of vWF with Coronary Artery Atherosclerotic Disease,R541.4
  12. Budd-Chiari Syndrome,R575
  13. The Study of Safe Ischemic Time of Endothelial Cells in Autologous Vein Graft,R654.3
  14. The Pathological Feature and Analysis Routine Elements of Drinking Water in Membranous Obstruction of the Primary Inferior Vena Cava Type of the Budd-Chiari Syndrome in Heze Area of Shandong Province,R575
  15. The Effect of Color Doppler Flow Imaging and Color Doppler Energy in the Diagnosis of Budd-chiari Syndrome,R575
  16. A Study on the Deficiency of Plasma PC Proteins and AT-Ⅲ in Chinese Patients with Budd-Chiari Syndrome,R575
  17. Epression and Clinical Significance of VEGF and TIMP-1 in the Liver of Patient with Budd-Chiari Syndrome,R575
  18. Research on the Histopathology and Related Factors of the Membrane in Budd-Chiari Syndrome (BCS),R575
  19. Research on Endothelial Injuries of Systemic Lupus Erythematosus,R593.241
  20. The Clinical Study of t-PA、PAI-1和GMP-140 Levels in Blood of OSAHS Patients,R56

CLC: > Medicine, health > Surgery > Of surgery > Abdominal surgery > Liver and liver tube
© 2012 www.DissertationTopic.Net  Mobile