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Objective: To investigate the degree of injury of intestinalmucosal barrier, the relationship between metabolic abnormalities ofexogenous hormone and intestinal barrier dysfunction, and the protectiveeffect of thyroid hormone（TH） in severe acute pancreatitis, Methods:Forty-two Wistar rats were randomly divided into 3 groups: sham group （SO）（n=10）, severe acute pancreatitis （SAP）group （n=15）, severe acutepancreatitis （SAP）group plus thyroid hormone （TH） group （n=17）. Serum FT3、FT4 level, and serum amylase, plasma endotoxin level in portal vein andinjure of intestinal mucosal grade were examined on 12h. Results: Incomparison with SO group, serum FT3、FT4level, and serum amyluse, plasmaendotoxin level in portal vein and injure of intestinal mucosal grade inSAP group were increased or decreased on 12h （P＜0.01）. In comparison withSAP group serum FT3、FT4 level, and serum amylase, plasma endotoxin levelin portal vein and injure of intestinal mucosal and pancreatitis gradein SAP group were increased or decreased on 12h （P＜0.01）, but comparisonwith SO group and TH group showed no significantly difference（P＞0.05）.Conclusions:along with injury of intestinal mucosal barrierof sever acute pancreatitis, the level of serum thyroid hormone decreasedand the level of plasma endotoxin increased. The supplement of additionalTH can protect intestinal mucosal barrier and alleviate injury ofintestinal mucosal barrier in rats with severe acute pancreatitis.
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