Dissertation > Excellent graduate degree dissertation topics show

The Influence of Atorvastatin on IL-6、hs-CRP and sVCAM-1 in Patients with Early Acute Coronary Syndrome

Author: SunYingJie
Tutor: ChenZuoYuan
School: Qingdao University
Course: Internal Medicine
Keywords: Acute coronary syndrome Atorvastatin IL-6 hs-CRP sVCAM-1
CLC: R541.4
Type: Master's thesis
Year: 2007
Downloads: 96
Quote: 0
Read: Download Dissertation

Abstract


Objective To observe the influence of atorvastatin on serum inflammation cytokines IL-6、high-sensitive C-reactive protein (hs-CRP) and sVCAM level in patients with acute coronarysyndrome(ACS), to know whether early intensive atorvastatin treatment may yield more significantbenefits in the patients of ACS.Methods Sixty-five patients of ACS were randomized to three groups: Group A(n=22) treated withatorvastatin from the first day, Group B(n=22) treated with atorvastatin from the first week, and GroupC (n=21) treated with atorvastatin from the second week, at the same time all the group treated withroutine therapy from the first day to the end. Serum IL-6、hs-CRP and sVCAM level of the threegroups were measured on the first week、the second week and the fourth week by enzymelinked-immuno-sorbent assay (ELISA).Results In all the groups: the concentrations of TC and LDL-C in group A remarkably decrease inthe end, there are statistical significance between the first week’s and the fourth week’s (P<0.01), butthere are no statistical significance in the Group B and Group C(P>0.01); the concentrations of TGand HDL-C in all the groups have no statistical significance between the first week’s and the fourthweek’s (P>0.05). The concentrations of hs-CRP、sVCAM-1 and IL-6 in group A remarkably decreaseon the first week、the second week and the fourth week, compared with the treament-before, there arestatistical significance between them(P<0.01); in group B, there are statistical significance between thesecond weeks’ and the fourth weeks’ in group C, there are statistical significance between the secondweeks’ and the fourth weeks’ (P<0.05). On the first week, there are statistical significance betweengroup A and group B、group A and group C (P<0.05); On the second week, there are statisticalsignificance between group A and group C、group B and group C(P<0.05); On the fourth week, thereare statistical significance between group A and group C、group B and group C(P<0.05).Conclusion Early treatment for ACS with atorvastatin can remarkably decrease the concentration ofserum inflammatory cytokines IL-6、hs-CRP and sVCAM-1, the anti-inflammation of atorvastatin hasno correaltion with its lipids suppression, early intensive atorvastatin treatment may yield moresignificant benefits in the patients of ACS.

Related Dissertations

  1. Inhibition of RAW264.7 Macrophage Inflammatory Cytokines Release by Guggulsterone,R285
  2. Infectious Bursal Disease Virus Particle Vaccine Research and Its Immune Efficacy Evaluation,S858.31
  3. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  4. The Effects of Atorvastatin on Expression of Osteopontin in Kidney of the Diabetic Rats Its Molecular Mechanism,R587.2
  5. The Expression and Significance of Nuclear Factor Kappa B (NF-κb) and IL-6 in the Degenerated Cervical Intervertebral Disc,R681.55
  6. Cysteamine on T Lymphocyte Proliferation in Post-Operation Goats and Its Mechanism Underlying,S858.27
  7. Cloning, Expression and Bioactivity Analysis of Goat Interleukin-1β and Interleukin-6,S827
  8. Meridians of Asthma Thread Burying Model Rats IL-4 Such Impact Experimental Study,R245
  9. Role of G31P in Smooth Muscle Migration of A7r5 Cells Induced by Interleukin-8,R363
  10. The Expression and Mechanism of NF-κ B and IL-6 after 90% Portal Vein Ligation in Rats,R657.3
  11. The Sequence Analysis of RNA Components from Lactobacillus Metabolites and Parts of the Biological Function,R378
  12. Noble Dendrobium Polysaccharides Attenuate Learning and Memory Deficits Induced by Lipopolysaccharide and Its Mechanisms in Rats,R285.5
  13. Effect of Grape Seed Procyanidins on the Blood Pressure in Renovascular Hypertensive Rats and Its Mechanism,R544.1
  14. The Relationship between TLR4 Protein Expression of Peripheral Blood Monocytes and the Pathogenetic Condition and Prognosis in Patients with Acute Coronary Syndrome,R541.4
  15. Effects of Intensive Antiplatelet Therapy for Patients with High On-treatment Platelet Reactivity After Coronary Stent Implantation,R541.4
  16. Biological Effects of Soluble CD40 Ligand on Leukemia HL-60 Cells and Its Mechanism,R733.7
  17. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  18. Clinical Observation of Ditan Soup in Treating PSD,R277.7
  19. Exploreing the Mechanism of Xieshifeiaifang Ii on Treating Lung Cancer with Pleura Effusion,R734.2
  20. The Preliminary Study of Growth-differentiation Factor-15 in Heart Failure Patients,R541.6
  21. Change and Value of Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Coronary Syndrome,R541.4

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)
© 2012 www.DissertationTopic.Net  Mobile