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Severe acute pancreatitis (severe acute pancreatitis, SAP) is a serious hazard to human health abdomen , its pathogenesis is still not fully elucidated. In recent years, research has focused on the disease itself in trypsin digestion doctrine ; inflammatory mediators doctrine ; pancreatic microcirculation doctrine ; intestinal bacterial translocation and the \Apoptosis is the body maintain their stable of basic physiological mechanism that pathogenesis of SAP advantageous to prevent necrosis of play and reduce the severity of SAP . Currently cell Bcl-2 protein family and pancreatitis -associated protein (pancreatitis associated protein, PAP) in the mechanism of apoptosis is the role of research focus , but they are in SAP pathogenesis and treatment of the role of research is still relatively small . Currently western GH (growth hormone, GH) and somatostatin (somatostatin, SST) , etc. and herbal TMP (telramethylpyrazine, TMP) in the treatment of SAP plays an important role , but their efficacy of combination therapy , in the treatment of Principle especially on the role of Bcl-2 protein family and the study of the Effect of PAP less ; Also , regarding the case of lignan compounds, with strong PAF antagonistic activity of traditional Chinese medicine in the treatment of SAP Kadsurenone efficacy and in the treatment of the role of the mechanism is also worth studying. In previous studies, this study on the basis of various indicators highlighted by observing the effect of TMP and Kadsurenone therapeutic effect on SAP , as well as during the treatment of pancreatic tissue Bax, Bcl-2 and PAP-1 changes in three genes situation and relationship with treatment outcome . The results found that TMP and Kadsurenone SAP has a better therapeutic effect , and in the course of drug treatment , short-term (48h) Bax gene expression was significantly decreased , while the Bcl-2 gene and PAP-1 gene expression was significantly increased , SAP plays the acute phase of apoptosis inhibition , and long-term (72h) has the opposite effect , inhibition of cell death plays a promoting their apoptosis.
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