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Study of a Class of Nano-Containers Based on Cyclodextrin Inclusion Complexation

Author: JiangChao
Tutor: QianXin；ZhouMi
School: Zhejiang University of Technology
Course: Materials Physics and Chemistry
Keywords: cyclodextrin inclusion complexation dendrimer hyper-branched polymer nano-containers
CLC: TB383.1
Type: Master's thesis
Year: 2011
Downloads: 41
Quote: 0
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Abstract


Nano-containers are usually nano-level hollow microspheres，which have numerous potential uses in biochemical and separation. Asthe second-generation representative of supramolecular chemistrycompounds, cyclodextrin can include with a variety of molecular, whichhas been extensive and in-depth studied.Because highly branched macromoleculars have the characteristicsof nano-scale size, large internal cavity and high-density functionalgroups on the outer layer, it is an ideal raw material to buildnano-containers. This article attempts to prepare two kinds ofsupramolecular functional nano-containers with the cores ofpolyamide-amine dendrimer macromolecules and hyperbranchedpolyamides-amine polymer through graftingβ-cyclodextrin to these twohighly branched macromoleculars by amine reaction. The key resultsinclude:1. Adopted a convenient way to successfully synthesize β-cyclodextrin surface modified polyamide-amine dendrimer andhyperbranched polyamides-amine polymer (PAMAM-β-CD andh-PAMAM-β-CD). These two kinds of polymer nano-containers bothhave excellent water solubility and inclusion ability with small moleculeβ-naphthol in the aqueous solution. They could play a role in drug controland supramolecular chemistry. Especially, h-PAMAM-β-CD shows greatpotential in industrial production and application for its relatively simpleand easy synthesis method.2. The results of 1H-NMR spectroscopy and elemental analysisproved that there is certain amount ofβ-cyclodextrin unit on the surfaceof PAMAM-β-CD polymer nano-containers. The UV-visible spectraresult of h-PAMAM-β-CD inclusion with small molecules showed thath-PAMAM-β-CD may contain moreβ-cyclodextrin units thanPAMAM-β-CD per molecule.3. UV-visible spectra confirmed that the PAMAM-β-CD polymernano-container includes the naphthalene end group of naphthaleneterminal methoxypolyethylene glycol (mPEG-N) in aqueous solution.Dynamic light scattering (DLS) and transmission electron microscopy(TEM) showed that PAMAM-β-CD and mPEG-N formed highlybranched-linear polymer assembly based on cyclodextrin inclusioncomplexation.

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