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Studies on the Surface Modification of Polymeric Vesicles and Supramolecular Hydrogels Based on the Inclusion Complexation Interactions

Author: GuoMingYu
Tutor: JiangMing
School: Fudan University
Course: Polymer Chemistry and Physics
Keywords: Cyclodextrin Inclusion complexation Hollow ball Supramolecular gels Quantum dots
CLC: O631.3
Type: PhD thesis
Year: 2009
Downloads: 448
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Abstract


In the past 20 years, our group proposed and the development of the concept of hydrogen-induced non-covalent bonding micelles \Recently, we turn to the Lord - the role of molecular recognition between the object introduced into the field of the self-assembly of macromolecules, to further expand and deepen the original NCCM research system. Of this research work is carried out on the basis of the existing research work in our group. Cyclodextrin with guest molecules inclusion complexation is mainly the use of polymer hollow sphere surface modification, self-assembled organic - inorganic hybrid the supramolecular gel preparation to commence a study: 1. Based on the inclusion complexation The role of the polymer surface of the hollow sphere-modified cyclodextrin as a host molecule is introduced into both ends of the semi-rigid polymer chain and found that the rigidity of the polymer of the end-modified monolayer hollow sphere structure may be formed in aqueous solution. PEG of different molecular weights as the host molecule of cyclodextrin are evenly distributed in this single-walled inner and outer walls of the hollow ball, and therefore can be further host - guest molecule inclusion complexation, using end adamantan modified to polymeric hollow sphere inside and the outer surface of a non-covalent modification. The research for the surface modification of polymer hollow spheres, especially its inner surface modification provides a simple new way to provide a great convenience for its applied research in many fields. Organic and organic based on low molecular weight PEG / α-CD - inorganic hybrid supramolecular gels many literature studies have shown that the high molecular weight PEG with α-cyclodextrin in aqueous solution by inclusion complexation formation supramolecular gels. Since the gel has a gel-sol temperature response to the nature of the changes in the form and shear thinning (shear-thinning), has a very good application prospects in the field of drug transport and release by extensive research workers. However, having a better biocompatibility of the low molecular weight PEG (Mn ≤ 2K) with the α-cyclodextrin was only formed crystals precipitate rather than gel. Our study found that single-ended adamantane modified low molecular weight PEG (Mn = 1.1 or 2K), due to the the adamantane hydrophobic aggregation, so that it can form supramolecular gels and α-cyclodextrin. At the same time, the surface of the β-cyclodextrin modified SiO 2 nanoparticles Complexation by β-cyclodextrin and adamantane package, well dispersed in the supramolecular gel , the formation of an inorganic nanoparticle hybrid gel. And the introduction of the β-cyclodextrin modified SiO 2 nano-particles can greatly improve the strength and viscosity of the hybrid gel. Further studies showed that the the hydrophobic aggregation area adamantane and β-cyclodextrin modified SiO 2 nanoparticles can be together, played a \Supra-cross-linker, referred to as SCL) role. 3. Zhi.A CdS quantum dots super crosslinker hybrid supramolecular gels in the above super crosslinker based on, in this section we take advantage of the supramolecular interactions between the main - guest molecules CdS as a super-modified cyclodextrin host molecules cross-linking agent for the preparation of hybrid supramolecular gel provides a simple and versatile new. Using this super crosslinker, with the various functions of the polymerization reaction of the water-soluble monomer can be obtained a variety of nanostructures hetero Supramolecular gel. In this hybrid Supramolecular gel systems, QDs through interaction stable inclusion complexation between the cyclodextrin with the guest molecules in the surface thereof uniformly dispersed in the gel. Prepared hybrid gel having excellent transparency and homogeneity such that it has very good application prospect in the various optical devices and biomedical materials field. 4. Based on the inclusion complexation CdS quantum dots hybrid between water-soluble supramolecular polymer network use of cyclodextrin and adamantane main - guest inclusion Complexation of CdS quantum dots super crosslinker to build a new water-soluble organic - inorganic hybrid supramolecular three-dimensional network structure. And characterized by TEM and AFM hybrid network structure. The fluorescence behavior of the solution showed that the supramolecular network structure does not damage the surface of CdS quantum dot structure, and may be effective to enhance the fluorescence intensity.

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CLC: > Mathematical sciences and chemical > Chemistry > Polymer chemistry ( polymer ) > Polymer physics and physical chemistry of polymers > The chemical nature of polymers
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