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Objective: To study computer syringe pump adrenaline continuous administration of of intermittent artificial intravenous injection of rabbit ventricular fibrillation hemodynamics and cerebral perfusion . Methods : 22 rabbits were randomly selected two as the sham-operated group , only surgical procedures , does not give cause fibrillation and cardiopulmonary resuscitation ( CPR ) ; remaining 20 were randomly divided into two groups , namely the continuous administration of epinephrine group ( experimental group , group A ) and intermittent administration group (control group , B group) . Thoracotomy epicardial electrical stimulation Preparation of ventricular fibrillation animal model , A group B group , the first a 20μg/kg manual bolus , then continuous infusion 10μg/kg/min 58min ; 20μg/kg 3min manual bolus 1 times , for a total of four times. Aortic systolic pressure measured during the experiment ( ASP ) , aortic diastolic blood pressure ( AOD ) , mean arterial pressure (MAP), central venous pressure ( CVP ) , intracranial pressure ( ICP ) , calculated coronary perfusion pressure ( CoPP ) cerebral perfusion pressure ( CEPP ) and were observed to affect the rate the rabbit ventricular fibrillation restoration of spontaneous circulation ( ROSC ) . ROSC 30min after injection of 10% fluorescein isothiocyanate - albumin mark blood ( 0.3g/kg ) cycle for 30 minutes after the animal brains were removed . Each rabbit slice three observed and photographed under a fluorescence microscope at 100 times . Image processing software IMAGEJ1.36 cerebral perfusion area , expressed as a percentage . Results: SPSS11.5 statistical software for statistical analysis , the experimental group of ASP , AOD , MAP , CoPP , CEPP were higher , there were no differences ( ventricular fibrillation ) , two groups of only TCP traffic from trusted hosts and CEPP were different ( p lt ; 0.05 ) . Experimental group of 10 patients successfully resuscitated eight cases of the control group, 10 cases of successful resuscitation in 6 cases, statistical analysis using Fisher's exact test , two sets of ROSC rate difference ( p = 0.628 , p gt ; 0.05 ) A group of cerebral perfusion area of ??62.35 ± 3.51 % , group B 31.92 ± 3.86 % , the difference was significant ( P lt ; 0.01 ) , while two of sham animals showed a uniform brain perfusion . Conclusion: epinephrine administration is continued with intermittent administration compared to a better hemodynamic effects and brain perfusion , therefore , the use of computer micro pump sustained delivery of superior to the traditional adrenaline mode of administration .
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