Dissertation > Excellent graduate degree dissertation topics show

Electroporation with a New Designed Microneedle to Enhance Insulin Transdermal Delivery and Decrease the Blood Glucose of Diabetes Rats

Author: CaiXiao
Tutor: XuYuHong；HuJun
School: Shanghai Jiaotong University
Course: Biochemistry and Molecular Biology
Keywords: Electroporation Microneedles Electrical pulse Diabetes Insulin Hydrogels
CLC: R587.1
Type: Master's thesis
Year: 2008
Downloads: 115
Quote: 0
Read: Download Dissertation

Abstract


Diabetes is a major issue plagued human insulin is an effective means for the treatment of diabetes , in the current administration of insulin by injection to a larger extent play to the efficacy of insulin , but the patient during the injection process , the need to endure injection pain. We therefore adopted the ring arrangement microneedles duration of 5ms, voltage 120V electrical pulses to the skin caused by water - based channels to enhance skin permeability to insulin . Experiments show that , without any treatment of the skin , insulin not through the microneedle electrode electrically induced hole means can be improved more effectively than simply using microneedle transdermal effect of insulin . And in order to treat conditions in SD rats pain test also confirmed that the treatment conditions to ensure the effect of insulin transdermal while managing to avoid induced strong rejection . This treatment combined with insulin hydrogel for the treatment of alloxan -induced diabetic mice , the treatment group, blood glucose decreased significantly, even lower than normal blood glucose levels , blood glucose while the control group only is rhythmic changes.

Related Dissertations

  1. Serum A-FABP Levels and Its Expression in Atherosclerotic Plaques of Diabetes Mellitus,R587.1
  2. Study on Relationship between Endothelin-1, Insulin Resistance and Acute Ischemic Cerebrovascular Disease,R743.3
  3. Improvement in Electroporation Transformation Efficiency of Gene for Bacillus Subtilis with Trehalose,Q78
  4. Professor Liu Yanchi academic thought and clinical experience and clinical studies for treatment of diabetes,R249
  5. Common TCM syndrome and serum homocysteine ??and diastolic function relationships of the newly diagnosed patients with type 2 diabetes,R259
  6. Efficacy and Safety of Biphasic Insulin Aspart 30 Once-daily Treatment in Patients with Type 2 Diabetes,R587.1
  7. The Blood Glucose Control and Influencing Factors in Type 2 Diabetic Patients with Oral Hypoglycemic Agents,R587.1
  8. Expression and Significance of HIF-1α on the Insulin Resistance during the Injury of Reperfusion of Ischemic Myocardium in Dog Undergoing Cardiopulmonary Bypass,R654.1
  9. Study on the Protein Composition of Intestinal Flora in the Antibiotics Interfered Mice and the Bacteria-related Diseases,R446.5
  10. Carotid Artery Wall Elasticity and Carotid Atherosclerosis in Diabetes Mellitus Patients with Microalbuminuria Using Ultrasonographic Elastography and High-freguency Ultrasound,R445.1
  11. Serum Levels of Insulin Like Growth Factor-1 and Cardiovascular Remodeling in Patients with Hypertension,R544.1
  12. Correlation Analysis between Coronary Lesion Severity and Peripheral Blood Cell CD34~+ Ratio in the Coronary Heart Disease Patients Complicating Diabetes Mellitus,R541.4
  13. Therapeutic Effect of Rosiglitazone on Chronic Obstructive Pulmonary Disease with Diabetes Mellitus,R587.1
  14. Relationship between Postprandial Blood Pressure and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus,R587.1
  15. Study Finds Best Use of Insulin as Diabetes Progresses and Impact Factors of Insulin Treatment of Diabetic Patients,R587.1
  16. Clinical Therapeutic Effect and Safety of Insulin Determir in Type 2 Diabetes Patients,R587.1
  17. The Comparative Analysis of the Effect to Diabetes of Insulin Pump and Hypoglycemic Agents,R587.1
  18. Analysis of the Insulin Dose and Impact Factors of Insulin Pump Treatment of Type 2 Diabetic Patients,R587.1
  19. The Influences of Blood Glucose Levels on the Function of Neutrophil-moncyte Cell Line HL-60 Cells,R587.1
  20. Differentiation Capacity of Periodontal Ligament Stem Cells of Chronic Periodontitis Patients with and Without Type 2 Diabetes Mellitus,R587.1
  21. The Effect on Maternal and Fetal in Pregnancy Associated with Diabetes,R714.7

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
© 2012 www.DissertationTopic.Net  Mobile