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Objective: through a hospital-based case-control study to explore the distribution law of the influencing factors of knee osteoarthritis. The screening of the influencing factors for knee osteoarthritis clinical treatment and prevention control provides a useful reference and recommendations for exploring the pathogenic factors of knee osteoarthritis the etiology clues and preliminary validation etiology assumptions. At the same time through a systematic analysis of the clinical features of knee osteoarthritis, to deepen the understanding of knee osteoarthritis TCM characteristics and clinical features of the law. Methods: this study from June 2007 to March 2008, admitted Affiliated Orthopedic Hospital of Guangzhou University of Traditional Chinese Medicine in patients with osteoarthritis of the knee and the corresponding matched controls to investigate the method of investigation for the face-to-face direct questions. Data collected using non logisitic regression analysis to calculate the various factors and knee osteoarthritis, the odds ratio (OR) and 95% confidence intervals. First fitting the The the single factor logisitic regression model initial screening statistically significant factors combine professional factors, in conjunction with the adjustment factors together fitting the multivariate unconditional logisitic regression model to analyze the knee joint to remove the confounding factors inflammation the relative independent risk factors and protective factors. Results: The survey received 200 valid data, including 100 cases of knee osteoarthritis now sick people control group of 100 cases. Analysis results are as follows: 1. Risk factors: body mass index (BMI) risk factors for knee osteoarthritis, the OR 23 = 1.951 (95% CI, :1.055-3 .061), OR BMI > 25 = 4.074 (95% CI :1.660-10 .000), residence buildings without elevators risk factors, OR = 5.500 (95% CI :2.239-13 .510), genetic factors are the risk factors for knee osteoarthritis, OR two = 7.971 (95% CI :3.274-19 .407), OR more than three = 13.333 (95% CI :2.389-74 .404), smoking are risk factors for knee osteoarthritis , drinking are risk factors for knee osteoarthritis, OR 1-3 times / week = 2.345 (95% CI :1.081-5 .089), OR daily = 2.549 ( 95% CI :1.052-6 .177), physical exercise too frequent risk factors for knee osteoarthritis, OR (2 times / week) = 2.787 (95% CI, :1.257-6 .182), bone mineral density is too high knee joint inflammation of the risk factors. OR = 7.487 (95% CI :1.251-44 .812). 2 protective factors: a day of tea protective factors for knee osteoarthritis, OR = 0.246 (95% CI :0.068-0 .897), beans (soy) protective factors for knee osteoarthritis, edible melon If the protective factors of knee osteoarthritis, OR daily = 0.182 (95% CI :0.034-0 .960). 3. Comprehensive multi-factor analysis showed that risk factors: body mass index (BMI) are risk factors of knee osteoarthritis, OR 23 = 3.682 (95% CI :1.332-10 .178) , OR BMI> 25 = 8.144 (95% CI :2.009-33 .018), smoking (> 20 cigarettes / day) the risk factors of knee osteoarthritis, OR > 20 cigarettes / day = 13.716 (95% CI :1.097-171 .487), drinking risk factor for knee osteoarthritis, the OR 1-3 times / week = 5.116 (95% CI :1.295-20 .211) , physical exercise is too often the risk factors of knee osteoarthritis, OR > 2 times / week = 28.677 (95% CI :1.591-516 .999). Protective factors: residence building elevator protective factors, OR = 0.047 (95% CI, about 0.003 to .880), daily tea protective factors for knee osteoarthritis, OR = 0.039 (95% CI, 0.004 to 0 .370) , of edible fruits knee osteoarthritis protection factors, OR days = 0.118 (95% CI, :0.014-0 .975). Analyzed the clinical features of 100 patients with knee osteoarthritis patients related evaluation of knee osteoarthritis imaging KL grading and knee ISOA grading, a correlation coefficient of 0.371 (P <0.05), there are statistics significance. Suggesting that the knee functional classification correlation imaging classification, a positive correlation. However, the correlation coefficient is less than 0.5, suggesting that the less strong correlation. 5 In this study, 100 patients with knee osteoarthritis patients mean BMD of 0.807 ± 0.153g/cm 2 , grading according to the imaging of bone mineral density analysis and comparison P> 0.05, no statistically significant. Conclusion: The regression method. By Non-conditions logisitic single factors initial screening of the main influencing factors for knee osteoarthritis using the multivariate unconditional logisitic regression statistical analysis again main factors, screening out the risk factors and protective factors, suspected or potential factor. 1.1 risk factors: The study found that the residence buildings without elevators, high body mass index, genetic factors in patients with both osteoarthritis, drinking habits, more physical exercise, increased the occurrence of knee osteoarthritis. 1.2 Protection of factors: The study found that regular tea drinking, regular consumption of fruits and decreased the risk of incidence of knee osteoarthritis. 1.3 suspicious or potential impact of factors: The study found that the consumption of soy products and bone mineral density as of knee osteoarthritis suspicious impact factors to be to continue to expand the sample size, and further research. Recommendation: This study found that the pathogenesis of knee osteoarthritis risk factors present in the life behavior and diet. Lifestyle through publicity and education, but also by the doctors to be guided to strengthen the sense of self-care, appropriate reasonable exercise, maintain a healthy lifestyle behaviors, optimistic and positive attitude towards life and improve the quality of life. Attention to nutritional balance diet, less alcohol, more tea, regular consumption of fruits, reasonably adjust dietary structure, reducing the likelihood of knee osteoarthritis. Through the analysis of the clinical features of knee osteoarthritis of knee osteoarthritis prone period before and after menopause, kidney osteoarthritis closely related. 4 speculated by statistical analysis of the bone mineral density of the different imaging classification of knee osteoarthritis, knee osteoarthritis and lumbar degenerative there is a correlation between the changes in bone mineral density may be caused due to the degeneration of the osteophyte. According imaging KL grading of knee osteoarthritis knee function ISOA grading correlation results, according to the Chinese traditional medicine \we think: in the process of the development of knee osteoarthritis, tendons Bi \\, will further enrich osteoarthritis of the knee dialectical system, play an important role in guiding clinical practice for osteoarthritis of the knee.
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