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Octreotide conventional chemotherapy drugs TACE treatment of advanced primary liver cancer experimental and clinical studies

Author: HuangMengJun
Tutor: MaYiLong
School: Guangxi Medical University
Course: Medical Oncology
Keywords: HCC TACE surgery Octreotide Treatment Control group
CLC: R735.7
Type: Master's thesis
Year: 2008
Downloads: 61
Quote: 0
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Abstract


Objective: To investigate octreotide combined with conventional chemotherapy drugs selective arterial chemoembolization treatment of advanced primary liver cancer mechanism and clinical value of understanding octreotide after interventional treatment of primary liver cancer caused by progressive liver fibrosis and after embolization-induced neoplastic Angiogenesis long-term adverse reaction. Methods: In my subjects interventional therapy in advanced unresectable primary liver cancer patients for the study, inclusion criteria were randomly divided into two groups according to liver cancer patients in the experimental group, 20 were selective transcatheter hepatic arterial infusion of octreotide 0.4mg, 5 - fluorouracil 1000mg, epirubicin 50mg, with mitomycin 10-14mg and 10-20ml Lipiodol Mixed tumor feeding artery embolization; control group of 20 people, selective transcatheter hepatic arterial infusion 5 - fluorouracil 1000mg , epirubicin 50mg, 10mg and lipiodol with mitomycin 10-20ml mixed tumor feeding artery embolization chemotherapy, all patients underwent TACE treatment three times, surgical intermittent period is 1 month; detected two groups of patients and third before 1 day after treatment, January AFP, vascular endothelial growth factor, hyaluronic acid, laminin, human procollagen type Ⅲ, Ⅳ collagen, LN laminin concentration values ??observed after treatment adverse reaction, measuring tumor size, relatively short-term effect, the measurement data t test or analysis of variance, grade column rank sum test, follow-up survival, Kaplan-merier method to calculate survival, survival curves depicted, Long-rank test to compare overall survival . Results: The two groups of patients before and after treatment serological comparison: after treatment than before treatment groups were alpha-fetoprotein values ??decrease, the difference was statistically significant (P <0.05), comparing the difference between the two groups was not statistically significant reduction (P> 0.05); after treatment than before treatment, vascular endothelial growth factor, hyaluronic acid, laminin, human procollagen type Ⅲ, Ⅳ collagen concentration, the difference was statistically significant (P <0.05), the control group increased more significantly than the experimental group, compared before and after the difference was statistically significant difference; term efficacy experimental group than the control group (P <0.05); compared with the control group, the experimental group after treatment, adverse reactions lighter, more patients can tolerate; experimental group 6 months, 1 year and 2-year cumulative survival rate was 100%, 84.2%, 36.9%; control group 6 months, 1 year and 2-year cumulative survival rate was 95%, 78.5%, 14 %; median survival of 23 months in the experimental group, the control group was 20 months, overall survival compared experimental groups than in the control group, the difference was statistically significant (P <0.05); Conclusion: Octreotide with conventional chemotherapy Drugs for the infusion of drugs on unresectable patients with advanced primary liver cancer chemoembolization can delay caused by repeated TACE liver fibrosis, decreased after embolization nascent tumor angiogenesis, reducing the likelihood of metastasis and recurrence, and can improve response rates recently, to a certain extent prolong survival, more effective than conventional chemotherapy infusion chemoembolization.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
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