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Objective: To observe of renal failure Xiezhuo Pill treatment of chronic renal failure rat model of efficacy, and explore its mechanism . Methods: adenine gavage to establish a rat model of chronic renal failure . Low the renal failure Xiezhuo pill treatment component , medium and high dose groups , set up as a positive control group Niaoduqing be distilled water , while the blank group, model group , to observe serum creatinine , urea nitrogen changes . Observed using immunohistochemical methods the renal tissues FN qualitative expression of TGF - β1 in tubulointerstitial . Results: the renal failure Xiezhuo pill to reduce serum creatinine, blood urea nitrogen content ; of renal failure Xiezhuo Pill can significantly cut the FN , TGF - β1 in renal tubules , interstitial expression , and the control group compared with a significant difference (p lt ; 0.05 ) ; of renal failure Xiezhuo pill able to improve the condition of the pathological damage of the renal tubules, interstitial . Conclusion: the renal failure Xiezhuo pill can reduce the adenine-induced renal failure rats reduce blood Scr , BUN improve renal function . The renal failure Xiezhuo pill can reduce the expression levels of FN, TGF-β1 in renal tissue , reduce tubular , interstitial inflammation, suppress the occurrence of renal interstitial fibrosis .
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