Dissertation > Excellent graduate degree dissertation topics show

The Study on the Molecular Mechanism of the Adipose Tissue as Targeting Tissue During the Course of Diabetes’s Therapy of Berberine

Author: LiuZuoZuo
Tutor: QinChuan
School: Beijing Union Medical College
Course: Pathology and Pathophysiology
Keywords: Adipose tissue Insulin Resistance Berberine Diabetes Diabetes treatment Adiponectin receptor Dyslipidemia Diabetic rats Insulin sensitivity Rosiglitazone Target tissues adipose Glucose and lipid metabolism insulin Adipogenesis Blood sugar Insulin sensitizers Lipid metabolism After treatment Endocrine function
CLC: R587.1
Type: PhD thesis
Year: 2008
Downloads: 58
Quote: 0
Read: Download Dissertation


Obesity and insulin resistance are more important health problem. The main features of adult obesity are the hypertrophy of adipocyte and the increase in the number of adipocyte. Adipose tissues are important organ which regulates glucose and lipid metabolism and the center of endocrine, paracrine and autocrine signals. Dysfunction of adipose tissues (adipose tissue insulin resistance) will lead to maladjustment of lipid metabolism in body which exhibit dyslipidomia and ectopic fat deposition in non-adipose tissues.Recently the antidiabetic characteristic of berberine is the hotspot of its pharmacology study. However, as an insulin-sensitizing drug, the therapeutic effect of berberine on adipose tissue insulin resistance is still unclear. In our study, we use the method which low-dose STZ was given based on high fat diet to induce type 2 diabetic hamster model. After that we mainly study the remedial effects of berberine on molecular mechanisms which lead to changes in isulin sensitivity of adipose tissues.The results indicated that berberine not only can improve hyperglycemia and dyslipidemia in diabetic states but also improve ectopic viscera fat deposition and ratio of big adipocyte in adipose tissues of type 2 diabetic hamsters to reverse ectopic fat deposition in non-adipose tissues and improve insulin resistance.Based on the results of microarry, we use the method of real-time PCR to study the gene change of adipose tissue in diabetic hamsters and berberine-treated diabetic hamsters. The results indicated the abnomal expression of SREBPs and its target genes, PPARa and its target genes, HSL, ATGL, GLUT, HK, ATP synthase, the decrease of adponectin and the increase of TNFαand IL-6 in adipose tissues of type 2 diabetic hamsters. After the treatment of berberine, the expression of SREBPs and its target genes, HSL and ATGL is decreased,that indicated berberine inhibit the synthesis and hydrolyzation/lipolysis of fat in adipose tissues of diabetic hamsters. At the same time, the expression of PPARa and its target genes, GLUT, HK and ATP synthase is increased, that indicated berberine help to uptake and metabolism of glucose and promote the oxidation of fatty acids and restore the Mitochondria function in adipose tissues. Berberine also induces the expression of adiponectin and reduces the expression of TNFaand IL-6, that indicate Berberine can improves endocrine function of adipose tissue and the state of chronic and lower inflammation of diabetes.In a word, berberine can effectively improve abnormal metabolism and function of adipose tissues under diabetic states, further improve dyslipidemia and ectopic fat deposition and insulin sensitivity to exhibit its therapeutic effect on type 2 diabetic mellitus. So adipose tissues are one of important common target tissues for berberine therapeutic effect to reduce blood glucose and improve insulin resistance.

Related Dissertations

  1. Studies on the Synthesis and Technology of Dipentaerythritol and Its Derivative,TQ223.164
  2. Preparation and Performance of Molecular Imprinted Polymers for Rhodamine-B and Rhodamine-6G,O631.3
  3. The Clinical Observation of Curative Effect Made by Differential Treatment of Refractory Thrombocytopenic Purpura,R259
  4. The Clinical Observation of the Lupus Detoxification Pill on Treating the Remission of Systemic Lupus Erythematosus,R259
  5. Effects of acupuncture on stroke recovery associated with depression and physical disabilities,R246.6
  6. Research of Glycosaminoglycan from Perna Virids Effect on Blood Lipid,R285.5
  7. Serum A-FABP Levels and Its Expression in Atherosclerotic Plaques of Diabetes Mellitus,R587.1
  8. The Preliminary Studies on Characteristics of HCV Quasispecies Variation and Its Immune Escaping Mechanism,R392.1
  9. Platelet parameters in patients before and after acute myocardial infarction,R542.22
  10. Study on Relationship between Endothelin-1, Insulin Resistance and Acute Ischemic Cerebrovascular Disease,R743.3
  11. Professor Zhang Shuwen academic thinking,and 59 cases of Chinese and Western medicine combined with clinical research for diagnosis and treatment of acute pancreatitis,R249.2
  12. Study on Nitrogen Removal by Soil Aquifer Treatment Process That Enhanced Nature Reoxygenation and Effective Volume,X703
  13. Study on the Combined Probiotics and Its Effects on Prodution Performance of Pigs,S828.5
  14. Pd-based cathode catalysts of direct methanol fuel cell,O643.36
  15. Synthesis and properties of new functionalized graphene oxide drug carriers,TQ460.4
  16. Study on Effect and Mechanisms of Hot Air Combined with MeJA on Quality Maintenance in Loquat Fruit,TS255.3
  17. Selection and Optimization of Control Technics in CODCr and Colority of the Refined Cotton Wastewater Treatment Process in a Refined Cotton Enterprise in Rudong, Jiangsu Province,X791
  18. Study on Drying Processing and Sterilization on Spinach,TS255.52
  19. Experimental Study of Improved UASB Reactor Treatment of Organic Wastewater,X703
  20. Mechanisms of Alleviating Effect of Seed Soaking with Soybean Isoflavones on Glycine Max, Salt-born Glycine Soja and Their Hybrid Seedlings under Salt Stress,S565.1
  21. Study on Characteristics of Morphology Anatomy and Physio-Biochemistry of Two Ecotype Varieties Cucumber Leggy Seedilings,S642.2

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
© 2012 www.DissertationTopic.Net  Mobile