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Somatostatin is a small molecule that regulatory peptides, it is widely inhibition of the physiological functions of the gastrointestinal tract, the thesis somatostatin analogue fat fed mice digestion, absorption, metabolism and oxidation of the original state impact, in order to clarify the oxidative reduction mechanism of state regulation, to improve the level of health of the body to provide a theoretical basis. Selected 64 male C57BL / 6 mice, divided into normal, high-fat, high-fat octreotide (OCT), fat 0.1% lipoic acid (LA), OCT group three weeks during the injection 0.1mlOCT (20ug/kg) row metabolism experiments, 3 weekend line glucose tolerance test (OGTT) and then sacrificed measured lipid parameters, digestion, absorption, metabolism tissue antioxidant indicators, duodenal and jejunal mucosal digestion enzyme levels. Other selected 112 male C57BL / 6 mice, grouped with the former, the OCT group of five weeks during the injection 0.1mlOCT (20ug/kg) 5w end of high-fat group was divided into three groups of obese in weight, obesity resistance, according to the weight each group were sacrificed half were injected with 0.1ml OCT and saline after 10min tails radicals and blood glucose blood test, and the next day put to death, measured lipid parameters, digestion, absorption, metabolism tissue antioxidant indicators, RT-PCR detection of ten expression in duodenum SS and IKKEmRNA. The results showed that: a 3-week high-fat diet will lead to weight gain in mice, reducing crude protein, dry matter, organic matter digestibility, protease, amylase activity was reduced, impaired glucose tolerance, dyslipidemia of ROS, MDA levels, antioxidant enzyme activity was reduced, compared with the high-fat group, the injection of OCT and add LA can reduce the body weight of mice, to raise crude protein, dry matter and organic matter digestibility, improve protease, amylase activity, relieve the state of impaired glucose tolerance, improve lipid metabolism, improve digestion, absorption, metabolism, antioxidant capacity of the organization; 5-week high-fat diet causes mice obese, BG, blood ROS levels, lipid metabolism disorders, MDA levels, antioxidant enzyme activity was reduced , IKKEmRNA upregulation injection OCT can reduce the weight of obese mice, reduce the BG blood ROS level, improve blood lipid metabolism, decreased MDA levels, improve the body's antioxidant capacity significantly raised SSmRNA expression to down IKKEmRNA expression, blood ROS BG, AI was a significant positive correlation was significantly negatively correlated with HDL, SS, ROS, AI level was a significant negative correlation. Conclusion: Increases injection OCT fat fed mice intestinal protease, amylase activity, improve the digestibility of nutrients to improve the high-fat diet causes impaired glucose tolerance, dyslipidemia, to reduce of obese mice BG and blood ROS levels significantly raised its SSmRNA expression, down expression of IKKEmRNA, lighten the weight of obese mice, reduce fat fed mice ROS and MDA levels, improve the body's antioxidant capacity.
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