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Research purposes to find a 50 g glucose load test (glucose challenge test, GCT) sector best value predicted gestational diabetes (GDM), Han Chinese pregnant women crowd solute carrier family 30, member8 (SLC30A8) gene rs13266634, rs2466293 and cyclin-dependent kinase 5 regulatorysubunit associated protein 1-like 1 (CDKAL1) gene rs10946398, rs9465871, rs7756992, rs7754840 single nucleotide polymorphism (SNP) allele, genotype frequency distribution and its relationship with metabolic indicators to understand the two genes GDM, to explore the value of GDM in pregnant women crowd gene polymorphisms predict. Research Methods This study included 1861 people, which GCT1h plasma glucose concentration <7.8mmol / L ie GCT negative pregnant women 300, 1561 cases of GCT positive subjects, GCT positive subjects further line 100g oral glucose tolerance test (OGTT) normal (NGT) 651 cases, 301 cases of in IGT, GDM patients, 609 cases. Draw the receiver operating characteristic curve (ROC) curve, ROC analysis, the assessment of insulin sensitivity and β-cell function with insulin sensitivity index ISI-Matsuda and insulin sensitivity-secretion index (ISSI). Ligase detection reaction to determine the genotype. Logistic regression analysis of the value of the predicted gene polymorphism with the identification of the area under the ROC curve assessing and forecasting model accuracy. 1 → GDM group from the NGT group → IGT group, insulin sensitivity index and insulin secretion index were lower (P <0.001). 2, with the of 50g GCT prediction of GDM under the ROC curve area of ??0.779 (95% CI :0.758-0 .800, P <0.001), more appropriate GCT 7.8mmol / L. 3, the case group SLC30A8 gene rs13266634 C allele frequency of the CC genotype frequencies were 56.9% and 35.2%, significantly higher than 46.3%, and 31.3% (P <0.05): and the case group TT genotype frequencies were 43.1% and 21.4%, significantly lower than the control group, 53.7% and 26.7% (P value <0.05). C allele T allele of 1.29 times the risk of suffering from impaired glucose tolerance, the CC genotype suffering the risk of impaired glucose tolerance is 1.47 times the TT genotype. The case group and control group rs13266634 genotype islet β-cell function (ISSI): CC genotype |