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The Clinical Research on Longchai Decoction Combined with Adefovir to Treat Chronic Hepatitis B

Author: ChenYongQing
Tutor: LiChunZuo
School: Nanjing University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Chronic hepatitis B Longchai decoction Liver-Stagnation and Spleen-Deficiency, middle energizer dampness-heat-toxin Adefovir clinic study
CLC: R512.62
Type: Master's thesis
Year: 2011
Downloads: 20
Quote: 0
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Abstract


Objective:To study the efficacy of the two groups in treating the syndrome of Liver-Stagnation and Spleen-Deficiency and middle energizer dampness-heat-toxin of Chronic Hepatitis B and to make the clinic effectiveness assessment of Traditional Chinese Medicine. Compared with Adefovir used only, to evaluate the curative effect of Adefovir combined with Longchai decoction in improving clinical symptoms, lowering enzymes, lowering virus quantity for patient of Chronic Hepatitis B.Methods:60 patients of Chronic hepatitis B were dividing into two groups randomly. The therapeutic group were treated with Adefovir orally10mg once daily combined with Longchai decoction liquid for two times in the morning and night,1 agent a day, while the control group were treated with Adefovir orally 10mg once daily only. The HBV Mark, HBV DNA, liver biochemical index, the Traditional Chinese Medicine (TCM) symptoms and manifestations were measured respectively at baseline,,12weeks and 24weeks. Then establishment of a database, analyze date using statistical software 16.0.Results:1. TCM symptom manifestations:After 24 weeks the symptom integration of the therapeutic group was 6.97±3.05, and the control group was 9.63±3.36 (P=0.034).the therapeutic group is better than the control group.2.The comparison of improvements in the liver function: After treatment, ALT, AST, y-GT, ALP, TBiL and DBiL are significantly improved, there are significant differences in reducing ALT, AST and ALP, the effect of the therapeutic group is better than the control group. After 12weeks, the therapeutic group ALT normalization rate was 23.3% while the control group was 16.7%. After 24 weeks, the therapeutic group ALT normalization rate was higher than the control group that was 53.33% vs 26.7%(p=0.035).3. Turning negative of HBeAg:After treatment, the therapeutic group HBeAg negative rate of 24.0%, and the control group HBeAg negative rate of 16.7%, there had no difference between the two groups (p=0.524).4.Virological response:After 24weeks, The whole response rate of the therapeutic group was 63.3% and the control group was56.7%, there had no difference between the two groups (p=0.601).The complete response rate of the therapeutic group was 23.3%, partical response rate was 40%, non-response rate was36.7%; the complete response rate of the control group was respectively 16.7%. partical response rate was 40% and non-response rate was 43.3%, there also had no difference between the two groups(p= 0.519).5. Comparison of side effects:There are no adverse reactions and side effects.Conclusion:The combination treatment of Adefovir combined with Longchai decoction on the syndrome of Liver-Stagnation and Spleen-Deficiency and middle energizer dampness-heat-toxin of Chronic Hepatitis B is superior than using Adefovir only on the aspect of improving clinic symptoms, protecting liver, anti-inflammatory and lowering enzyme. Longchai decoction is reasonable and effective, and suitable for clinical studies.

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CLC: > Medicine, health > Internal Medicine > Infectious disease > Viral infections > Viral Hepatitis > Hepatitis B
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