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Establishment of Rat-Model of Invasive Pulmonary Aspergillosis and Therapeutic Effect of Compound Fuzhengkemei on Rat-Model

Author: ZhouHai
Tutor: WangXin
School: Shandong University
Course: Clinical
Keywords: Invasive pulmonary aspergillosis To righting grams mold side Rat model of invasive pulmonary aspergillosis
CLC: R519.8
Type: Master's thesis
Year: 2011
Downloads: 12
Quote: 0
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Abstract


The purpose of invasive pulmonary aspergillosis early diagnosis is difficult, antifungal efficacy is not so good reasons invasive pulmonary aspergillosis become an important cause of death in patients with hematologic malignancies and hematopoietic stem cell transplant recipients. In this study, by constructing rat invasive pulmonary aspergillosis model, evaluation of compound righting n-grams mildew square on the treatment of invasive pulmonary aspergillosis in rats. After gavage to rats by intraperitoneal injection of cyclophosphamide immune suppression status, endotracheal intubation inoculated with Aspergillus fumigatus spore suspension, rat invasive pulmonary aspergillosis model compound righting g mycophenolate side treatment, point in time to take blood samples, lung tissue specimens, evaluation of compound righting g mold side of the treatment of invasive pulmonary aspergillosis in rats by the serum galactomannan (Galactomannan GM) detection, lung histopathological examination. Rats inoculated with Aspergillus fumigatus mental deterioration, reduced activity, decreased appetite, body curled a series of performance, and weight loss. Inoculated with Aspergillus fumigatus rats in the first 3 days after inoculation, blood line GM detection result was 1.214 ± 0.626, not in rats inoculated with Aspergillus fumigatus 3rd day blood line the GM detection result as 0.360 ± 0.106 (P lt; 0.001). 2 pathological examination of the lung tissue of rats inoculated with Aspergillus fumigatus find hyphae of Aspergillus fumigatus. Treatment group rat the righting g mycophenolate Treatment of GM value is 0.720 ± 0.291, the Aspergillus fumigatus control group rat The GM values ??saline 1.383 ± 0.592 (P lt; 0.001). Average survival days of treatment group rats to 12.9 ± 4.8 days, and the average survival days of Aspergillus fumigatus control rats was 9.9 ± 3.2 days (P = 0.027). Conclusion rats were inoculated with Aspergillus fumigatus after a series of performance, day 3 serum GM results and lung pathology results are rats with invasive pulmonary aspergillosis model was successfully constructed. Application of compound righting grams mold treatment side of the rat study found that: Compound righting grams mold significantly reduce the level of serum GM of invasive pulmonary aspergillosis in rats, and can significantly prolong the survival time of invasive pulmonary aspergillosis in rats. Lung tissue morphology of the treated rats was significantly improved to alleviate the severity of inflammation, consistent with the decreased levels of GM and the prolongation of the survival time. This study suggests that the compound for righting grams mold side has a therapeutic effect on rats with invasive pulmonary aspergillosis.

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CLC: > Medicine, health > Internal Medicine > Infectious disease > Fungi and actinomycetes infectious diseases > Other
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