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Experimental Study of Effects of Contrast-enhanced Ultrasound Guided Local Hemostatic Injection Treatment in Hemorrhage Renal Trauma

Author: XuYanJun
Tutor: ZhouXiaoDong
School: Fourth Military Medical University
Course: Medical Imaging and Nuclear Medicine
Keywords: CEUS Renal trauma Active bleeding Thrombin Short-term efficacy
CLC: R445.1
Type: Master's thesis
Year: 2011
Downloads: 3
Quote: 0
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Abstract


Objective: To study the CEUS -guided local injection of hemostatic agents feasibility and short-term efficacy evaluation of the treatment of traumatic renal hemorrhage . Methods: 25 New Zealand white rabbits , purebred prepared Ⅲ ~ Ⅳ grade renal trauma animal model , the whole experiment to monitor and maintain mean arterial pressure 70mmHg (1 mm Hg = 0.133 kPa ) . Were randomly divided into 2 groups , the CEUS clear bleeding site . CEUS -guided therapy group, 15 in the trauma stove thrombin injection , 10 control group injected with saline . 2 groups were treated in line CEUS again five minutes . Treated 1 h, conventional ultrasound measurements of renal subcapsular hematoma range , the determination of the amount of intraperitoneal free fluid parallel pathological examination immediately after the animals were killed . Results: ultrasound contrast the treatment group showed no active bleeding , the control group still shows a small amount of active bleeding . Treatment of renal subcapsular hematoma range ( 11 ± 2 ) mm × ( 18 ± 7 ) , and the control group ( 16 ± 5 ) mm × ( 22 ± 8 ) mm , no statistically significant difference ; two groups of free intraperitoneal liquid amount of approximately ( 13 ± 5 ) ml and (76 ± 11) ml, the former is significantly less than the latter , P lt ; 0.05 . Laparotomy see the the treatment group trauma stove local coverage clot bleeding stopped completely ; control group of Focal see a little blood clots and bleeding wounds still visible . Conclusion : CEUS can quickly identify the location and degree of renal trauma hemorrhage ; its hemostatic injection therapy guided operation method is simple , fast , and effective inhibition of renal trauma with active bleeding , better short-term efficacy .

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CLC: > Medicine, health > Clinical > Diagnostics > Diagnostic Imaging > Ultrasonic diagnosis
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