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Objective: extracted from traditional Chinese medicine Litchi separation of the a hypoglycemic effective parts and the parts of the chemical constituents of . Methods: Animal experiments and alpha - glucosidase enzyme activity assay screening activity of litchi seed extract fractions on the effective part of the chemical nature of the research , the use of phenol - sulfuric acid method . By repeated silica gel column chromatography , Sephadex LH - 20 and other means of separation and purification , Litchi effective parts to be separated. And the use of spectral analysis their structures were identified . Results: Litchi ethanol extract has a significant hypoglycemic effect of type II diabetic rats , significantly inhibited alpha - glucosidase inhibitory activity stronger than the positive drug in the same concentration , consistent with the results of animal experiments in vivo ; litchi extract fractions , of BF , BFWD and BFWI of total sugar and total phenolic content were not significantly different, and total saponins different , respectively, 21.96% , 6.54% , 46.06 % ; litchi 50 % ethanol extraction portion 10 of the monomer compound was isolated , identified by the structure of each compound , respectively, for the carrot the glycoside ( Dancosterol ) , protocatechuic aldehyde (Protocatechuic aldehyde), quercetin ( quercetin ) , 5 - methoxy- - uridine ( 5- Methoxyuridine ) , powder fern prime ( onychin ) , Qiaosong prime - 7 -O - beta - D - grape glycoside ( pinocembrin - 7 - - neohesperi - doside ) , beta - valley steroid alcohols ( beta - sitostero ) , D - 1-O- methyl - muscle - myo-inositol ( D - 1 -O - methylmyo -inositol ) , protocatechuic acid ( proto - catechuic acid ) . 5 - methoxy - uridine for the first time from Litchi isolated . Conclusion: The use of alpha - glucosidase has of hypoglycemic active chemical ingredients as Litchi screening model , a simple and workable . Has laid a solid theoretical basis for clinical application Litchi treatment of diabetes .
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