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Synthesis and Antidepressant Activity of N-(2-hydroxyethyl) Cinnamam Derivatives

Author: WuDi
Tutor: QuanZheShan
School: Yanbian University
Course: Medicinal Chemistry
Keywords: Fluoxetine Forced swimming test Tail suspention test 5-Hydroxytryptophan (5-HTP) induced mouse head-twitch test Yohimbine toxicity potentiation test
CLC: R285
Type: Master's thesis
Year: 2011
Downloads: 76
Quote: 0
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Abstract


In order to finding better compounds with antidepressant activity, a series of N-(2-hydroxyethyl) cinnamam derivatives (3a-3n) were synthesized using benzaidehyde as the starting materials to evaluate their antidepressant effects. Most of the compounds significantly reduced immobility times during the suspention test (TST) at a dose of 40 mg/kg indicative of their antidepressant activity. Among the compounds,3b, 3j,31 showed the best antidepressant activity, Which decreased the immobility time by 48.91%,36.61%,69.99% and 48.91%,76.35%,57.43% in FST and TST respectively at 40 mg/kg dose level (i.p). According to the results of the 5-HTP induced head-twitch test and yohimbine toxicity potentiation test, the noradrenergic system seems not to be involved in the antidepressant-like effect of compound 3b,3j,31

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