Dissertation > Excellent graduate degree dissertation topics show

Synthesis and Antidepressant Activity of N-(2-hydroxyethyl) Cinnamam Derivatives

Author: WuDi
Tutor: QuanZheShan
School: Yanbian University
Course: Medicinal Chemistry
Keywords: Fluoxetine Forced swimming test Tail suspention test 5-Hydroxytryptophan (5-HTP) induced mouse head-twitch test Yohimbine toxicity potentiation test
CLC: R285
Type: Master's thesis
Year: 2011
Downloads: 76
Quote: 0
Read: Download Dissertation


In order to finding better compounds with antidepressant activity, a series of N-(2-hydroxyethyl) cinnamam derivatives (3a-3n) were synthesized using benzaidehyde as the starting materials to evaluate their antidepressant effects. Most of the compounds significantly reduced immobility times during the suspention test (TST) at a dose of 40 mg/kg indicative of their antidepressant activity. Among the compounds,3b, 3j,31 showed the best antidepressant activity, Which decreased the immobility time by 48.91%,36.61%,69.99% and 48.91%,76.35%,57.43% in FST and TST respectively at 40 mg/kg dose level (i.p). According to the results of the 5-HTP induced head-twitch test and yohimbine toxicity potentiation test, the noradrenergic system seems not to be involved in the antidepressant-like effect of compound 3b,3j,31

Related Dissertations

  1. Study on the Stereoselective Synthesis of Anti-Mdd Drugs with Chiral α-Substituted Secondary Alcohol as Key Intermediate,TQ463
  2. TCM treatment of depression Kidney Liver Depression and stagnation and spleen deficiency - clinical study,R277.7
  3. Polymorphism of Serotonin Transporter Gene Influences Core Symptoms and Treatment Response with Fluoxetine for Major Depression,R749.4
  4. Serotonin System and Hormone Circadian Rhythm Research in Depression,R749.4
  5. Polymer supported chiral catalysts in the asymmetric synthesis of chiral secondary alcohols,O643.3
  6. The Protective Effects of Brain-derived Neurotrophic Factor in Acute Mentally Stressed Rats and the Intervention of Fluoxetine,R749.5
  7. Association between Polymorphism of Serotonin Transporter Gene in Major Depression and Therapeutic Response and Adverse Effect with Fluoxetine Treatment,R749.4
  8. Effect and Possible Mechanism of Habenular Nucleus in the Regulation of Adenosine on Behavior of Depressed Rats Induced by CUMS,R749.4
  9. Of novel cyclodextrin chiral stationary phase prepared fluoxetine Enantiomers,O657.7
  10. Regulation of cAMP Responsive Element Binding Protein to Stress in Rat Amygdala and Hippocampal Formation,R329
  11. Supported catalyst in the asymmetric reduction reaction in the palladium-catalyzed reaction of prochiral ketone,O621.25
  12. Habenula in the rat pathogenesis of depression and possible mechanisms,R749.4
  13. Study on Neuroprotect Actions of Fluoxetine Against the Focal Cerebral Ischemia-reperfusion Injury in Rats and Anoxia-reoxygenation Injury of Rat Hippocamal Neurons in Vitro,R743.3
  14. Study on Analytical Methods and the Pharmacokinetics of Fluoxetine and Norfluoxetine,R96
  15. Studies on Changes in CREB Signal Pathway of the Brain and Stress Hormone Levels of Plasma in Ethanol Dependent Rats,R749.62
  16. The Study on the Principle of CRH,ACTH,NPY and GAL in Depression and its Mechanism,R749.4
  17. Estradiol and fluoxetine for depression rat model of behavior , and 5 - serotonin neurotransmitter system effects,R749.4
  18. Behavioral and Hippocampal Cytoskeletal Alterations in Rats Following Chronic Unpredictable Mild Stress and Fluoxetine Treatment,R749.4
  19. The Clinical and Molecular Biological Mechanism Study of Ningdong Granule on Tourette’s Syndrome,R272
  20. Fluoxetine hydrochloride regulation of neural stem cell signaling pathway downstream gene expression experiments,R749.4
  21. Kv1.5 and anti- apoptosis-related proteins in rat pulmonary hypertension fluoxetine mechanism of action in,R96

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology
© 2012 www.DissertationTopic.Net  Mobile