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Objective: To observe the TCM for type 2 diabetes, phlegm, blood stasis in patients with non-PBSS general, conventional indicators and adiponectin levels, homocysteine ??levels, revealing type 2 diabetes phlegm, blood stasis of the objective laws of plasma adiponectin, homocysteine ??in patients with type 2 diabetes vascular complications of chronic pathological role for TCM objective to provide laboratory basis, but also provide a theoretical basis for the prevention and treatment of traditional Chinese medicine. Method: 1, the grouping method: From 2009.11-2010.9 to First Clinical Medical College of Zhengzhou University medical treatment of the patients, collected qualifying 112 patients with type 2 diabetes, according to TCM is divided into 43 cases of phlegm, blood stasis 30 cases and 39 cases of non-phlegm group. And the establishment of the normal control group of 35 patients. 2, Observation Project: General Project: gender, age, duration, weight, height, body mass index, symptoms, tongue, pulse, complications. Biochemical project: fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), serum insulin (FINS), insulin resistance index (HOMA-IR). Pilot projects: adiponectin (APN) measured by ELISA, homocysteine ??(HCY) using high performance liquid chromatography. Result: a gender comparison was no significant difference between the groups (P gt; 0.05). Age comparison group than phlegm stasis, phlegm and blood stasis syndrome group differences were not statistically significant (P lt; 0.05). Course comparison group than phlegm stasis, phlegm and blood stasis syndrome group non-long duration, the difference was statistically significant (P lt; 0.01). 2 body mass index, phlegm stasis syndrome group was significantly higher than the non-phlegm syndrome group and normal control group (P lt; 0.01). Fasting blood glucose compared phlegm group BSS group than non PBSS group, but the difference was not statistically significant (P gt; 0.05). HbA1c% compared with phlegm and blood stasis syndrome group was no significant difference between the groups, but were significantly higher than non-phlegm syndrome group (P lt; 0.05). HOMA-IR: phlegm syndrome group gt; BSS group gt; non PBSS group, the difference was statistically significant (P lt; 0.01 P lt; 0.05). 3 TG comparison group phlegm, blood stasis group was significantly higher than non-phlegm syndrome group and normal control group (P lt; 0.01, P lt; 0.05); phlegm and blood stasis was no significant difference between the two groups (P gt; 0.05). About TC and LDL-c, phlegm group, blood stasis phlegm and blood stasis syndrome group and non-group difference was not statistically significant (P gt; 0.05). HDL-c phlegm syndrome group was significantly lower than the other groups (P lt; 0.01). 4 HCY comparison group phlegm, blood stasis was no significant difference between the groups, but were significantly higher than non-phlegm syndrome group and normal control group (P lt; 0.01). APN comparison group phlegm, blood stasis group was significantly lower than the control group (P lt; 0.01). Phlegm and blood stasis syndrome group were significantly lower than group non PBSS group, the difference was statistically significant (P lt; 0.01). 5 stasis combined and chronic vascular complications in 21 cases, the incidence was 70%; phlegm combined and chronic vascular complications in 23 cases, the incidence rate of 53.49%; non PBSS combined and chronic vascular complications in 11 cases, incidence rate of 28.21%; incidence of the three groups were significantly different (P lt; 0.05). 6, respectively, blood stasis, phlegm syndrome by Yin heat, Qi, yin and yang deficiency syndrome, the blood stasis in the distribution of more than three certificates were 6.67%, 36.67%, 56.67%; sputum turbid were 39.53%, 51.16%, 9.31%. 7 HCY, APN there is evidence of vascular complications in patients with and without vascular complications syndrome group difference was statistically significant (P <0.01) Conclusion: a phlegm, blood stasis and chronic vascular complications may exist common pathophysiological basis. 2 adiponectin, homocysteine ??can be used as phlegm, blood stasis syndrome of objective indicators and monitoring vascular complications reference. 3 phlegm and blood stasis exists in the incidence of diabetes, the development of the whole process, the clinical use of blood and phlegm treatment is important.
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