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Objective: 1 through the clinical observation kidney detoxification side, the impact of the patient's symptoms and laboratory indicators of the active phase of deficiency the toxic stasis lupus nephritis (LN), evaluation of a kidney detoxification combined Western medicine treatment of LN with active clinical value; 2 by determination of serum prolactin (PRL), to explore the relationship between PRL and LN patients disease activity and renal damage extent; 3 observation of LN activity of patients before and after the PRL change, evaluation and kidney detoxification combined western medicine clinical efficacy of the PRL. Methods: 1, 42 patients with LN activity in patients with the principles of simple random sampling (random number table) is divided into a treatment group and a control group, each of the 21 cases, the control group according to the disease conventional western medicine to conventional western medicine treatment group plus kidney detoxification square Oral: compare before and after treatment in each group and the two groups after treatment, the clinical symptoms, clinical syndrome integral and laboratory indicators; chemiluminescence detection of 42 cases the LN of active patients, 15 patients with LN relatively quiescent patients and 15 healthy examination PRL levels. Results: 1 LN with active patients before treatment PRL levels significantly higher than the level of LN quiescent patients (P lt; 0.01), LN quiescent patients PRL levels significantly higher than the level of healthy subjects (P lt; 0.01); The clinical efficacy of the treatment group, the total effective rate of 90.5%, the clinical efficacy of the control group, the total effective rate of 76.2%, the clinical efficacy of the treatment group and the control group the total efficiency difference was statistically significant; statistical differences in clinical symptoms in the treatment group and the control group after treatment significance (P lt; O.05), of which treatment group the effect of improving fever, palpitations, dysphoria heat significantly better than the control group (P lt; 0.01), erythema in improving the patient's face, mouth sores, dry mouth the effect is also superior to the control group (P lt; 0.05), improve joint pain, swelling of aspects no significant difference (P gt; 0.05); 3 patients with LN with active PRL LN degree of renal injury was a significant positive correlation (P lt ; O.01) LN with active PRL levels in patients with anti-double-stranded DNA antibody titers (ds-DNA) and the SLEDAI score level was a significant positive correlation (P lt; 0.01); 4, the treatment group and the control group, each group therapy after and before treatment, PRL, 24 h urinary protein excretion, serum creatinine, serum albumin, hemoglobin, C-reactive protein, immunoglobulin IgG, complement C3, C4, antinuclear antibodies (ANA), anti-double stranded DNA antibodies (ds -DNA) laboratory indicators showed significant improvement (P lt; O.05), but the treatment group and the control group after treatment, in addition to the anti-nuclear antibody (ANA), anti-double stranded DNA antibodies (ds-DNA), no significant difference in the reactive protein, immunoglobulin IgG, the I laboratory parameters to improve the situation are the treatment group were better than the control group after treatment (P lt; 0.05). Conclusion: LN serum PRL levels in patients with LN disease activity, the PRL as one of the indicators of the judgment LN disease activity. 2, kidney detoxification square with western medicine Yin toxic stasis lupus nephritis active patients, with good results in improving clinical symptoms and improve the overall clinical efficacy, compared with the control group significantly improve certain laboratory indicators efficacy, but to reduce the positive rate of ANA and anti-double-stranded DNA antibodies (ds-DNA), C-reactive protein, immunoglobulin IgG, there was no better than the effect of the control group.
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