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Objective: To explore the heart and brain Tongluo liquid focal cerebral ischemia in rat plasma OX- LDL , PECAM -1 content influence to provide experimental basis for clinical drug guidance cerebral infarction . Methods: SD rats were randomly divided into five groups , the sham group , model group , heart and brain Tongluo liquid high-dose group ( referred to as the high-dose group ) , cardio-cerebral the Tongluo fluid low-dose group ( low-dose group ) step Naoxintong control group (control group) . Intraluminal middle cerebral artery model of focal cerebral ischemia , 6h after the success of the model , 12h , 24h batches OX- LDL in plasma PECAM -1 levels were measured by ELISA . Results: 1. Cardiovascular tongluo liquid focal cerebral ischemia in rats plasma OX-LDL content : sham group at the same time point , each surgical group plasma OX-LDL levels increased : with the model group at the same time point In comparison , high cardiovascular tongluo liquid , low- dose group , the control group OX-LDL levels decreased , cardio-cerebral the Tongluo liquid high-dose group and at the same time point the control group showed no significant difference ( P gt ; 0.05) ; same group , the difference was not statistically significant ( P lt; 0.05 ) , at different time points OX-LDL content . 2 . Cardiovascular tongluo solution of focal cerebral ischemia in rat plasma PECAM-1 content : Compared with the sham group , the surgery group plasma PECAM-1 was increased to 24h to reach the peak ( P gt ; 0.05 ); compared with the model group at the same time point , plasma PECAM-1 have different levels of each treatment group ( P gt ; 0.05) , the highest content of high dose group ; point high- dose group and the control group was not statistically significant between the . Conclusions : 1 . Cardiovascular Tongluo Yexian lower focal cerebral ischemia in rat plasma OX-LDL content , the effective protection of the ischemic injury caused by focal cerebral infarction . 2. Heart and brain tongluo solution can be by elevated PECAM-1 content of focal cerebral ischemia in the rat plasma , inhibit platelet adhesion , aggregation and secretion , and inhibition of thrombus around the platelet activation , thus limiting the thrombus volume expansion , reduce brain tissue injury .
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