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Background: The incidence and mortality of coronary heart disease (CHD) is increasing year by year, how to prevent the disease, is one of the important and difficult for the field of cardiovascular disease research. Proof of clinical and evidence-based medicine, antiplatelet therapy in coronary heart disease secondary prevention focus. Currently often used antiplatelet western medicine and blood circulation of proprietary Chinese medicines, prevention and treatment of coronary heart disease. Research found that the role of antiplatelet western medicine fast, single action target, but it is easy to produce drug resistance; blood circulation Herb target of more, and with a variety of anti-coagulant and anti-platelet function role, but play a slower effect mild, the role is difficult to quantify. Clinical use of proprietary Chinese medicines blood circulation mostly without the Chinese medicine diagnosis and treatment, traditional Chinese medicine and western medicine used in combination there is not standardized, clinical efficacy judgments just from the symptoms, signs and laboratory examinations, and less from molecular biochemical indicators to evaluate its efficacy , and no description of their combined effect is synergistic, additive or partially antagonized. This prompted us to expand from the clinical efficacy and molecular biochemical indicators the reasonable combination therapy of coronary heart disease of the blood circulation proprietary Chinese medicines and anti-platelet western medicine and the study of angina pectoris TCM and objective indicators related to its purpose coronary heart disease TCM syndrome and its standardized treatment to provide certain reference. Objective: study blood circulation of proprietary Chinese medicines, and the reasonableness of aspirin therapy on chronic stable angina, chronic stable angina in Western medicine combined treatment of standardized treatment regimens provide an objective basis. 2, observed with chronic stable angina TCM syndrome type distribution to explore chronic stable angina TCM syndrome type and platelet aggregation rate (PAG), P-select prime (CD62P) and platelet membrane glycoprotein Ⅱ b / Ⅲ a composite material (GP Ⅱ b / Ⅲ a) and the hemorheological level relationship, for coronary heart disease in Chinese medicine syndrome type provide an objective basis to rely on modern medical research means to quantify TCM Syndrome Types to guide clinical treatment. Method: 1, choose the 76 cases of patients with chronic stable angina, disable the blood circulation of proprietary Chinese medicines two weeks after single aspirin were randomly divided into treatment group (aspirin group) 25 cases, the use of TCM blood circulation proprietary Chinese medicines aspirin treatment group ( standard treatment group) and 17 cases, 34 cases of Chinese medicine dialectical use of the blood circulation of proprietary Chinese medicines aspirin treatment group (the customary treatment group) treatment for 3 months, respectively, with a platelet aggregometer, flow cytometry, blood viscosity measured platelet aggregation rate (PAG), P-select prime (CD62P) and platelet membrane glycoprotein protein Ⅱ b / Ⅲ a composite material (GP Ⅱ b / Ⅲ a), hemorheological indicators, and compare three groups of treatment before and after and between the 3 groups PAG, of CD62P, the GP Ⅱ b / Ⅲ a, hemorheology changes and clinical efficacy. 2, 76 patients with chronic stable angina patients, divided into sub-standard TCM heart blood stasis, blood stasis, qi stagnation type 3, platelet aggregation meter, flow cytometry, blood viscometer Determination of PAG, CD62P and GP Ⅱ b / Ⅲ a, hemorheology, and 3 the syndrome type above indicators to compare. 3, all data processing applications SPSS12.0 statistical software measurement data expressed as mean ± standard deviation (x ± s), the same group before and after treatment using paired t test groups were compared using one-way ANOVA. P lt; 0.05 significant difference statistically significant. Results: 1 standard therapy group therapy PAG, CD62P, GP Ⅱ b / Ⅲ a, hemorheology, TCM permit candidates before the total score than treatment significantly decreased (P lt; 0.05), their GP Ⅱ b / Ⅲ a, TCM certificate climate total score of The decline in value significantly greater than in the aspirin group and customary treatment group (P lt; 0.05), PAG, low shear whole blood viscosity, erythrocyte rigidity index and erythrocyte aggregation index decreased value significantly greater than the customary treatment group (P lt; 0.05). Although the aspirin group, erythrocyte aggregation index, erythrocyte deformation index and habits therapy group plasma viscosity than treatment significantly significantly decreased (P lt; 0.05), but the 2 groups of patients after treatment PAG, CD62P, GP Ⅱ b / Ⅲ a TCM certificate climate total score compared with treatment former no significant change (P gt; 0.05). The three groups of patients with angina pectoris total score before and after treatment were no significant differences (P gt; 0.05), but the standard treatment group angina downward trend in the total score than before treatment (P = 0.069). 2, blood stasis type GP Ⅱ b / Ⅲ a level significantly higher than that of Qi and blood stasis type (P lt; 0.05), compared with blood stasis type, Qi and Blood Whole blood viscosity levels significantly increased (P lt; 0.05) erythrocyte aggregation index decreased significantly (P lt; 0.05); blood stasis type, Qi and Blood, qi stagnation syndrome type CD62P, PAG no significant difference (P gt; 0.05). TCM syndromes conclusions: 1, based on the use of TCM blood circulation proprietary Chinese medicines on the basis of the use of aspirin can significantly inhibit platelet aggregation, anti-platelet activation, improve blood rheology, and significant improvement in patients with chronic stable angina, to a certain extent to improve the symptoms of angina. Anti-platelet activation and improve the role of traditional Chinese medicine syndrome compared with aspirin alone, and dialectical use of the blood circulation of proprietary Chinese medicines in combination with aspirin significantly, suggesting that in the treatment of chronic stable angina, blood circulation of proprietary Chinese medicines based on the use of Chinese medicine syndrome joint Aspirin can achieve better clinical effect. Blood stasis type GP Ⅱ b / Ⅲ a higher Qi and Blood and blood stasis type were elevated whole blood viscosity, erythrocyte aggregation index characterized by elevation. GP Ⅱ b / Ⅲ a, hemorheology as an indicator of chronic stable angina microscopic of dialectical and efficacy assessed, and guiding significance for the treatment of chronic stable angina medication.
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