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Animal Experimental Study of the Degradable Cage

Author: HaoYong
Tutor: ZhouYue
School: Third Military Medical University
Course: Surgery
Keywords: Bone fusion PLA PDLLA Biodegradable Interbody fusion Absorbable material
CLC: R687.1
Type: PhD thesis
Year: 2003
Downloads: 68
Quote: 0
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Abstract


[Abstract] Objective: biodegradable materials in recent years, the gradual rise of new bio-engineered materials used in clinical tissue compatibility, and can be degraded and absorbed by the body itself, the molecular weight, the mechanical properties of the material in the synthesis adjusting the reaction conditions by artificial regulation. These characteristics developed interbody fusion device made of biodegradable material (PDLLA), applied to the experimental animals were observed biodegradable interbody fusion bone fusion, and the degradation of bone fusion process, simultaneously by mechanical testing, examine the biomechanical changes, and its significance in the case of the animal experiments, and to provide the basis of animal experiments for further improvement and clinical applications. Method: ① reference literature biodegradable materials at home and abroad interbody fusion developed interbody fusion cage made of biodegradable material. ② Compared with the control group of normal bone fusion by histology, electron microscopy and other methods to understand the use of biodegradable material interbody fusion bone fusion in experimental animals at different stages of bone graft fusion. ③ Compared with the control group of normal bone fusion, by general observation, electron microscopy to understand the degradation and absorption of the different stages of the absorbent material in the process of bone fusion. (4) through biomechanical testing, the different stages of the detection of spinal fusion using biodegradable the biomechanical changes interbody fusion interbody fusion. Results: ① with a molecular weight of 80 × 104 high molecular weight PDLLA material success made interbody fusion, fusion cube type. ② In the early and middle of the interbody fusion, bone fusion process is not significantly impact fusion late, due to an increase in a degradation product of the material, as well as the presence of the material itself, after degradation of bone fusion slowly, the performance of the gradual degradation of the material and material surrounding cartilage, fibrous tissue calcification gradually. Integration of parts of the final complete bone fusion. ③ the degradation rate of the material in the process of interbody fusion is non-uniform, in the early stages, the material mainly for the hydrolysis of the surface material, decrease in the molecular weight with material layers hydrolysis gradually accelerated internal degradation rate since catalysis accelerate , collapse of the final material, decomposition. ④ material mechanical strength than bone tissue, the early mechanical results show that the compressive, torsional strength were significantly higher, late as the degradation of the mechanical properties of the material change gradually with the control group results similar. The full text of conclusions: biodegradable PDLLA interbody fusion of the organization does not cause significant immune rejection, histocompatibility. PDLLA material fusion design basically meet the the the interbody fusion physiological and biomechanical design requirements. PDLLA material negative impact on the process of bone fusion, the late degradation products have some negative impact on the process of bone fusion to cause the late degradation rate of the material is slower than the organization osteogenesis speed. But the final material can be organized completely absorbed, the original portion is gradually replaced by new bone tissue. In early can maintain its base lt; WP = gt; the shape, mechanical strength in the latter significantly decreased, but sufficient to maintain bone fusion process, the fusion of the bone graft site after the gradual decomposition of strength decline and eventually collapse disintegration . Therefore, PDLLA a good tissue compatibility, good absorbing material meet the requirements of the interbody fusion strength. By improvements such as adding bone induction or the bone conduction component, and a surface treatment, to improve cell attachment, reducing the material around the time of early degradation histologic response, promoting the degradation of its post, while improving the ability to promote osteoblast more to promote its therapeutic application process

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CLC: > Medicine, health > Surgery > Orthopaedic Surgery ( movement system diseases,orthopedic surgery ) > Orthopedic surgery and surgery > Technology and equipment
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