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Clinical Study and Experimental Research on the Therapeutics Effects of ZuoGuiShuangJiang Decoction on Cases with Hypertension Disease Complicated from Type 2 Diabetes

Author: YiWei
Tutor: ChenDaShun
School: Hunan College of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Diabetes, hypertension Qiyinliangxu Chief hyperactivity of liver yang Normalized double down the left side Human umbilical vein endothelial cell line Endothelin Cell adhesion molecule Nitric oxide Yin and Yang Freemasons method
CLC: R259.8
Type: PhD thesis
Year: 2004
Downloads: 173
Quote: 0
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Abstract


Objective: To investigate the prevalence of diabetic patients with hypertension in Zhuzhou, Hunan and TCM syndrome distribution characteristics, observed to the \mechanism Zuogui double down side, try to find new ways recognizable syndromes with basic pathogenesis of diabetic hypertension. : Hunan College of Traditional Chinese Medicine attached admitted three-Hospital Diabetes Center from 1998 to 2003, 1200 patients with type 2 diabetes hospitalization data for analysis, choose from October 2002 to November 2003 hospitalization of 60 patients with type 2 diabetes and high blood pressure The patients were divided into two groups the, the Qiyinliangxu and the hyperactivity of liver yang given Diamicron were given basic hypoglycemic therapy based on the normalized double down the left side, captopril, oral treatment for 4 weeks before and after treatment the diabetic hypertensive efficacy, TCM syndrome, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, blood pressure changes, and to compare them. The same time, through the establishment of the model of vascular endothelial cell injury induced by glucose, insulin, low-density lipoprotein, the observed morphological changes in human umbilical vein endothelial cell line Zuogui double down Prescription and NO, ET-1, the expression of ICAM -1 and other indicators of change, in order to further investigate the mechanism left to normalized double down side the treatment of diabetes, hypertension. : Diabetes hypertension incidence of 31.2%, the TCM pathogenesis due to deficiency of both qi and yin liver yang, the the normalized double down the left side treatment the diabetic hypertensive total effective rate of 90%, the improvement rate was 93.3 TCM syndromes % Diamicron synergistic hypoglycemic effect and can reduce blood glucose, glycosylated hemoglobin, blood pressure; vitro cultured human umbilical vein endothelial cells Experimental results show that the double down Zuogui can only significantly reduce the content of ET, to improve the content of NO, and can inhibit the secretion of ICAM-1, vascular endothelial cells with the protection, regulation of vasomotor function. Conclusion: Zhuzhou incidence of diabetes, hypertension, consistent with the literature. Extensive Qi and Yin Chief liver yang in diabetic hypertensive syndrome distribution, \show that the double down Zuogui side has the protection of vascular endothelial cells, the role of the can before thrombosis is effective prescription for the treatment of diabetes, hypertension.

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