Dissertation > Excellent graduate degree dissertation topics show

Mapping the Locus for Congenital Preauricular Fistula and a Study of the Candidate Gene to Schizophrenia

Author: ZouFangGeng
Tutor: HeLin
School: Shanghai Institutes for Biological Sciences
Course: Neurobiology
Keywords: Congenital Preauricular Fistula Linkage analysis Schizophrenia G72/G30 Transmission/disequilibrium test
CLC: R749.3
Type: PhD thesis
Year: 2004
Downloads: 146
Quote: 0
Read: Download Dissertation

Abstract


The thesis contains two main pieces of work. In the first one, wemapped the locus for Congenital Preauricular Fistula using linkageanalysis based on a large family. In another piece of work, we studiedthe linkage and assciation between the SNP in G72/G30 genes andschizophrenia in the Han Chinese population using atransmission/disequilibrium test. Congenital Preauricular Fistula (MIM 128700) is a common auricularabnormality, the incidence of which is around 1%. The formation of CPFis closely associated with embryological development of the auricle,which is developed from the first and second branchial arches. In thiswork, we have first mapped the locus for CPF onto chromosome 8q11.1-q13.3using a family composed of 7 affected and 11 normal subjects. The LOD scorewith two-point linkage analysis is 2.40 shown by markers D8S285 andD8S1113 at recombination fractionθ=0.00. The results from another threemarkers (D8S1110, D8S260 and D8S1136) in the same region further supportthe linkage. The haplotype analysis for this family confined the locuswithin an interval of approximately 26.7 cM flanked by markers D8S532 andD8S279. Studies have shown a strong positive association betweenschizophrenia and G72/G30 genes, demonstrated by both individual markers 2<WP=4>先天性耳前瘘管基因定位及精神分裂症候选基因分析and haplotypes. A further functional study also supports the role of G72in the etiology of schizophrenia. In this study, we have replicated theseresults of transmission/disequilibrium test and haplotype analysis in theHan Chinese population, showing P values of 0.0018 and 0.00007 forindividual markers and haplotypes, respectively. Hence, our data supportsthe hypothesis that G72/G30 genes are important candidate genes forexplaining schizophrenia in the Han Chinese population.

Related Dissertations

  1. Four kinds of atypical antipsychotics in patients with schizophrenia serum prolactin and Blood Lipid,R749.3
  2. The Efficacy Compare between Psychosurgery and Drug Therapy in Refractory Schizophrenia,R749.3
  3. Effects and Mechanisms of Different Atypical Antipsychotic Agents on Glucose and Lipid Metabolism in Schizophrenic Patients,R749.3
  4. Study on Association of Borna Disease Virus Infection with Encephalitis and Schizophrenia,R512.3
  5. Association between SNP and Haplotypes in ALOX12 Gene and Peak BMD and Obesity Related Phenotypes Variation in the Chinese Nuclear Families,R589.2
  6. Association between Schizophrenia and Lipoprotein Lipase Gene,R749.3
  7. 6-week, Randomized, Opened, Comparison of the Efficacy and Tolerability of Ziprasidone and Olanzapine in Schizophrenic,R749.3
  8. Association Study between IL-1β/IL10 Gene Polymorphism and Schizophrenia,R749.3
  9. The Genetic Study of Epidermolytic Palmoplantar Keratoderma in a Uighur Family,R758.5
  10. The Relationship of Glucose Metabolism and Serum Level of Interleukin-1 in First-episode Drug -na(?)ve Schizophrenia: a Case-control Study,R749.3
  11. Bivariate Whole Genome Linkage Analysis for Obesity and Osteoporosis,R580
  12. A Soul of the Poetry Belonging to Night: On Poems of Huiwa,I207.25
  13. Initial Mapping of a Pedigree with a Chinese Family with Familial IgA Nephropathy,R692.3
  14. The Neuropsychological Study of Executive Function in Adolescent with Bipolar Disorder before and after Treatment,R749.4
  15. A Controlled Study of Short-term Systemic Family Therapy for Schizophrenics,R749.3
  16. Cost and Effectiveness Analysis on Inpatient Care of Schizophrene between Two Different Hospitals,R749.3
  17. Effects of Ketamine-induced Symptoms Similar to Schizophrenia in Mice and Its Mechanisms,D919
  18. An Archetypal Study of the Journals of Susanna Moodie,I711
  19. Study on the Schizophreniform Symptoms of the Mice Induced by Ketamine and Effects of MAPK Signal Pathway,R749.3
  20. Initial Studies and Realization Based on SNPs of Schizophrenia,R749.3
  21. Study of the Association between the Prostaglandin E Receptor 3 Gene Polymorphism and Schizophrenia,Q75

CLC: > Medicine, health > Neurology and psychiatry > Psychiatry > Schizophrenia
© 2012 www.DissertationTopic.Net  Mobile