Dissertation > Excellent graduate degree dissertation topics show

The Experimental Study on Relationship between Angiopoietins/Tie-2 Axis and Diabetic Renal Microvascular Disease

Author: YangYiBin
Tutor: HuangSongMin
School: Sichuan University
Course: Internal Medicine
Keywords: Diabetic nephropathy Angiopoietins Tie-2 Angiogenesis
CLC: R587.1
Type: PhD thesis
Year: 2005
Downloads: 209
Quote: 0
Read: Download Dissertation

Abstract


Backgrounds and research purposes sustained abnormally high blood sugar first led to endothelial cell damage , diabetic nephropathy (diabetic nephropathy, DN) of the occurrence and development of endothelial dysfunction is closely related to , or in the early diabetic kidney DN stage renal morphology has been confirmed there is a small ball angiogenesis . Angiopoietin (angiopoietins, Ang) is a newly discovered and vascular endothelial growth factor (vascular endothelial growth factor, VEGF) collaborative involvement of physiological and pathological angiogenesis cluster of protein molecules , Ang-1 and Ang-2 is Ang the two most important members of the family . Studies have shown that the main cause of VEGF immature , unstable and a leakage initial vascular network formation , and Ang-1 subsequent to promote their mature, stable and functional , Ang-2 Ang-1 is competitive inhibition factor , is to start again plastic vessel type the key factor in the presence of VEGF induced angiogenesis , VEGF is lacking promote vascular atrophy. VEGF and DN has confirmed the occurrence and development , but rarely Ang structural abnormalities and diabetic renal microvascular relationships reported. This paper through the diabetic animal model, continuous observation of multiple points Ang-1, Ang-2, Tie-2 and Thrombomodulin-1 (TM-1) expression in diabetic kidney to study in diabetic kidney Ang/Tie-2 the variation , understanding hamster kidney angiogenesis explore Ang/Tie-2 diabetic renal microvascular structure with changes in the relationship . Methods Male SD rats , standardized feeding. Let the two groups and the control of diabetes ,

Related Dissertations

  1. Effects of Angiogenic Factor on Follicular Angiogenesis and Development in Immature Mouse,S865.13
  2. Inhibition of Conventional Chemotherapy Combined with Metronomic Chemotherapy on Breast Cancer Xenografts in Nude Mice,R737.9
  3. The Experimental Study of Antiangiogenic and Induction of Apoptosis by Maximum Tolerated Dose Combined with Low-dose Cyclophosphamide in Breast Cancer,R737.9
  4. Maximum Tolerated Dose Combined with Metronomic Chemoterpy on Proliferation and Angiogenesis in Treatment of Breast Cancer,R737.9
  5. Astudy on Base Station Omni-directionalantennas for MIMO Communications,TN828.6
  6. Effect and Mechanism of Asiatic Acid on Angiogenesis,R285.5
  7. Clinical Effection on Abnormal Expression of the Angiopoietin-1&-2 and Receptor Tie-2 in Human Intracranial Aneurysms,R651.1
  8. TCM retention enema treatment of diabetic nephropathy,R259
  9. Analysis on the Problems of Anxi Tieguanyin Product Brands and Suggestions to the Problems,F426.82
  10. Study on Characteristics of Inter-area Low Frequency Power Oscillation in Interconnected Power Grid,TM712
  11. Study on the Function of Angiogenesis in Gastrointestinal Carcinoma Invasion and Metastasis,R735
  12. Modern tie-dye process characteristics and its creative application of fashion design,J523.5
  13. On the Regional Culture Features of Tie Ning’s Fictions,I207.42
  14. Study of Comparison in Offensive Match Using between Inside and Outside Players in Both China and Foreign Countries,G841
  15. Research on Virtual Logistics Enterprise Partner Selection Problem of Tie Long Company,F259.23
  16. Effects of Lysyl Oxidase on Cell Adherence, Migration and Angiogenesis in Vitro,R96
  17. Effect of ATRA on Mesangial Cell Proliferation Induced by High Glucose in Rat,R587.2
  18. Effect of Tumor-associated Macrophages on Endometrioid Adenocarcinoma,R737.33
  19. The Expression and Significance of VEGF, VEGFR-1 and VEGFR-2 in Condyloma Acuminatum,R752.53
  20. Effects of rhNrg-1β on Angiogenesis and VEGF Expression in Ischemic Myocardium of Rats After Acute Myocardial Infarction,R542.22
  21. Study on Cerebral Lymphatic Drainage Pathway in Acute Cerebral Infarction with Diabetes mellitus in Rats,R743.3

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
© 2012 www.DissertationTopic.Net  Mobile